Grisar Koenraad, Dok Ruveyda, Schoenaers Joseph, Dormaar Titiaan, Hauben Esther, Jorissen Mark, Nuyts Sandra, Politis Constantinus
Department of Oral and Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium.
Laboratory of Experimental Radiotherapy, University of Leuven, Leuven, Belgium.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 May;121(5):456-60. doi: 10.1016/j.oooo.2015.10.035. Epub 2015 Nov 17.
This study investigated the prevalence of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) and compared patient profiles and outcomes between HPV-positive and HPV-negative groups.
This retrospective study included all patients treated for OPSCC in the University Hospitals of Leuven between 2004 and 2012. Paraffin-embedded tumor tissue was available for all patients. Patient characteristics, treatment, and follow-up data were retrieved from medical files. HPV status was determined by immunohistochemical staining for the p16 epitope.
Among 94 patients, the prevalence of HPV-positive OPSCC was 22.34%. Compared with HPV-negative tumors, HPV-positive tumors were correlated with less smoking and alcohol consumption, tonsillar sublocalization (P < .05), and younger age. HPV-positive OPSCC was associated with better overall survival (62.2%) compared with HPV-negative OPSCC (42.5%; P = .0588).
Among patients with OPSCC, those with HPV exhibited profiles different from those without HPV. HPV-positive OPSCC was associated with better overall survival compared with HPV-negative OPSCC. HPV-positive OPSCC prevalence increased over time.
本研究调查了人乳头瘤病毒（HPV）相关的口咽鳞状细胞癌（OPSCC）的患病率，并比较了HPV阳性和阴性组患者的特征及预后。
这项回顾性研究纳入了2004年至2012年期间在鲁汶大学医院接受OPSCC治疗的所有患者。所有患者均有石蜡包埋的肿瘤组织。从医疗档案中获取患者特征、治疗及随访数据。通过对p16表位进行免疫组化染色来确定HPV状态。
在94例患者中，HPV阳性的OPSCC患病率为22.34%。与HPV阴性肿瘤相比，HPV阳性肿瘤与吸烟和饮酒较少、扁桃体亚定位（P <.05）以及年龄较轻相关。与HPV阴性的OPSCC（42.5%；P = 0.0588）相比，HPV阳性的OPSCC总生存率更高（62.2%）。
在OPSCC患者中，HPV阳性患者的特征与HPV阴性患者不同。与HPV阴性的OPSCC相比，HPV阳性的OPSCC总生存率更高。HPV阳性的OPSCC患病率随时间增加。
