Li Meng-Hua, Zhang Xing, Li Feng-Jiao, Gao Xian-Lu, Yan Shi-da, Lin Qiao-Hong, Li Xi-Yuan, Meng Jian, Zhang Ying, Zhang Shi-Ting, Chen Shu-Wei, Song Ming
Department of Head and Neck Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, China.
State Key Laboratory of Oncology in South China, Guangzhou, China.
Head Neck. 2025 Aug;47(8):2248-2259. doi: 10.1002/hed.28143. Epub 2025 Mar 27.
Squamous cell carcinoma of the soft palate (SCCSP) represents a rare subtype of oropharyngeal cancer. This study aims to evaluate the treatment outcomes of SCCSP and to assess the prognostic significance of HPV status.
Patients diagnosed with SCCSP between January 1981 and December 2021 were collected. Survival outcomes were compared.
In univariate analysis, primary surgery resulted in superior progression-free survival (PFS), overall survival (OS), and disease-specific survival (DSS) compared with definitive radiotherapy (p < 0.05). Furthermore, multivariate analysis revealed that primary surgery independently correlated with superior PFS (HR = 0.37, p = 0.002), OS (HR = 0.55, p = 0.012), and DSS (HR = 0.45, p = 0.020) in early-stage SCCSPs. Additionally, no significant prognostic differences were observed between HPV/p16 positive and HPV/p16 negative SCCSPs (p > 0.05).
Surgery yields superior oncological outcomes for early-stage SCCSP patients. HPV status does not demonstrate prognostic significance in SCCSP.
软腭鳞状细胞癌（SCCSP）是口咽癌的一种罕见亚型。本研究旨在评估SCCSP的治疗效果，并评估人乳头瘤病毒（HPV）状态的预后意义。
收集1981年1月至2021年12月期间诊断为SCCSP的患者。比较生存结果。
单因素分析显示，与根治性放疗相比，一期手术的无进展生存期（PFS）、总生存期（OS）和疾病特异性生存期（DSS）更佳（p < 0.05）。此外，多因素分析显示，在早期SCCSP中，一期手术与更好的PFS（风险比[HR]=0.37，p = 0.002）、OS（HR = 0.55，p = 0.012）和DSS（HR = 0.45，p = 0.020）独立相关。此外，HPV/p16阳性和HPV/p16阴性的SCCSP之间未观察到显著的预后差异（p > 0.05）。
手术对早期SCCSP患者产生更好的肿瘤学结果。HPV状态在SCCSP中未显示出预后意义。
