社区居民中肾动脉钙化与高血压的关联：动脉粥样硬化的多民族研究。
The association of renal artery calcification with hypertension in community-living individuals: the multiethnic study of atherosclerosis.
作者信息
Thomas Isac C, Ratigan Amanda R, Rifkin Dena E, Ix Joachim H, Criqui Michael H, Budoff Matthew J, Allison Matthew A
机构信息
Division of Cardiovascular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA 92037, USA.
Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA 92037, USA.
出版信息
J Am Soc Hypertens. 2016 Feb;10(2):167-74. doi: 10.1016/j.jash.2015.12.003. Epub 2015 Dec 13.
Hypertension (HTN) is a modifiable risk factor for cardiovascular disease (CVD). Renal artery calcium (RAC) may signal the presence of flow-limiting atherosclerotic disease that may contribute to changes in the kidney's regulation of blood pressure. We hypothesized that RAC is independently associated with HTN. We examined a multiethnic cohort of 1285 participants who underwent abdominal computed tomography scans in five US communities. After adjustment for age, gender, race/ethnicity, CVD risk factors, abdominal aortic calcium score, and kidney function, the presence of RAC was associated with a 50% higher odds of HTN (odds ratio: 1.54; 95% confidence interval 1.11-2.13). Similarly, the presence of RAC was associated with a 8.5 mm Hg higher systolic blood pressure, a 2.1 mm Hg higher diastolic blood pressure, and a 7.4-mm Hg higher pulse pressure. In conclusion, independent of CVD risk factors, abdominal aortic calcium, and kidney function, the presence of RAC is associated with HTN prevalence.
高血压（HTN）是心血管疾病（CVD）的一个可改变的风险因素。肾动脉钙化（RAC）可能提示存在限制血流的动脉粥样硬化疾病，这可能导致肾脏血压调节功能的改变。我们假设RAC与HTN独立相关。我们研究了来自美国五个社区的1285名参与者的多民族队列，这些参与者均接受了腹部计算机断层扫描。在调整了年龄、性别、种族/民族、CVD风险因素、腹主动脉钙化评分和肾功能后，RAC的存在与HTN患病几率高出50%相关（比值比：1.54；95%置信区间1.11 - 2.13）。同样，RAC的存在与收缩压高8.5 mmHg、舒张压高2.1 mmHg以及脉压高7.4 mmHg相关。总之，独立于CVD风险因素、腹主动脉钙化和肾功能，RAC的存在与HTN患病率相关。
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