拉坦前列素/噻吗洛尔与曲伏前列素/噻吗洛尔固定组合治疗葡萄膜炎相关性高眼压症的疗效和安全性评估。
Evaluation of Efficacy and Safety of Latanoprost/Timolol versus Travoprost/Timolol Fixed Combinations for Ocular Hypertension Associated with Uveitis.
作者信息
Takeuchi Masaru, Kanda Takayuki, Taguchi Manzo, Shibata Masaki, Mine Izumi, Sakurai Yutaka
机构信息
a Department of Ophthalmology , National Defense Medical College , Tokorozawa, Saitama , Japan.
出版信息
Ocul Immunol Inflamm. 2017 Feb;25(1):105-110. doi: 10.3109/09273948.2015.1092559. Epub 2016 Jan 22.
PURPOSE
To compare latanoprost/timolol (LT) versus travoprost/timolol (TT) fixed combinations for ocular hypertension (OHT) associated with uveitis.
METHODS
Thirty-six patients (55 eyes) who were treated with LT (28 eyes) or TT (27 eyes) for OHT associated with uveitis were reviewed retrospectively. Intraocular pressure (IOP) and inflammation scores at the initiation of treatment and at the last visit during therapy were analyzed.
RESULTS
Although IOP was reduced significantly in both LT and TT groups, the reduction rate was significantly greater with TT group than with LT. The differences in the reduction of IOP between the groups remained significant when the cases were classified into inflammation-induced OHT and steroid-induced OHT. Inflammation score was not exacerbated by LT or TT treatment.
CONCLUSIONS
Both LT and TT are safe and effective for the treatment of OHT associated with uveitis and greater IOP reduction may be achieved by TT than by LT treatment.
目的
比较拉坦前列素/噻吗洛尔（LT）与曲伏前列素/噻吗洛尔（TT）固定组合用于治疗与葡萄膜炎相关的高眼压症（OHT）的效果。
方法
回顾性分析36例（55只眼）接受LT（28只眼）或TT（27只眼）治疗与葡萄膜炎相关的OHT的患者。分析治疗开始时及治疗期间最后一次就诊时的眼压（IOP）和炎症评分。
结果
虽然LT组和TT组的IOP均显著降低，但TT组的降低率显著高于LT组。当将病例分为炎症性OHT和类固醇性OHT时，两组间IOP降低的差异仍然显著。LT或TT治疗均未使炎症评分加重。
结论
LT和TT治疗与葡萄膜炎相关的OHT均安全有效，且TT治疗降低IOP的效果可能优于LT治疗。
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