Department of Dermatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
Clin Rheumatol. 2021 Jul;40(7):2985-2989. doi: 10.1007/s10067-020-05523-4. Epub 2020 Nov 26.
Calcinosis cutis (CC) is defined as the deposition of calcium salts on the skin and subcutaneous tissue. It is associated with different conditions, including some autoimmune diseases, and it can generate significant inflammation, pain, and functional impairment. Different therapies have been tried with limited results. Intralesional sodium thiosulfate seems a promising therapeutic option. We report a patient with diffuse systemic sclerosis who presented with two symmetrical plaques on both axillae, which caused pain and skin retraction. The clinical diagnosis was consistent with CC, which was confirmed by skin biopsy and ultrasound. The patient was treated with a 250 mg/ml solution of sodium thiosulfate injected into the plaques. Complete resolution was achieved after three monthly sessions. The only reported adverse effect was a transient burning sensation during the injections. Given its effectiveness and safety, we believe that intralesional sodium thiosulfate could become a valid first-line option for the treatment of CC.
钙沉积症（CC）是指钙盐在皮肤和皮下组织中的沉积。它与多种疾病相关，包括一些自身免疫性疾病，可导致严重的炎症、疼痛和功能障碍。目前已有多种疗法尝试，但疗效有限。局部注射硫代硫酸钠似乎是一种有前途的治疗选择。我们报告了 1 例弥漫性系统性硬化症患者，其双侧腋窝出现两个对称斑块，引起疼痛和皮肤收缩。临床诊断符合 CC，皮肤活检和超声检查结果也支持这一诊断。患者接受了 250mg/ml 硫代硫酸钠溶液局部注射治疗。三次每月一次的治疗后，斑块完全消退。唯一报告的不良反应是注射过程中短暂的烧灼感。鉴于其有效性和安全性，我们认为局部注射硫代硫酸钠可能成为 CC 的一种有效一线治疗选择。
