Recho Pierre, Ranft Jonas, Marcq Philippe
Mathematical Institute, University of Oxford, Oxford OX26GG, UK and Sorbonne Université, UPMC Univ Paris 06, Institut Curie, CNRS, UMR 168, Laboratoire Physco-Chimie Curie, Paris, France.
Laboratoire de Physique Statistique, École Normale Supérieure, 24 rue Lhomond, F-75231 Paris Cedex 05, France.
Soft Matter. 2016 Feb 28;12(8):2381-91. doi: 10.1039/c5sm02857d.
The importance of collective cellular migration during embryogenesis and tissue repair asks for a sound understanding of underlying principles and mechanisms. Here, we address recent in vitro experiments on cell monolayers, which show that the advancement of the leading edge relies on cell proliferation and protrusive activity at the tissue margin. Within a simple viscoelastic mechanical model amenable to detailed analysis, we identify a key parameter responsible for tissue expansion, and we determine the dependence of the monolayer velocity as a function of measurable rheological parameters. Our results allow us to discuss the effects of pharmacological perturbations on the observed tissue dynamics.
集体细胞迁移在胚胎发育和组织修复过程中的重要性要求我们对其潜在原理和机制有深入的理解。在此，我们探讨了近期关于细胞单层的体外实验，这些实验表明前沿的推进依赖于组织边缘的细胞增殖和突出活动。在一个适合详细分析的简单粘弹性力学模型中，我们确定了一个负责组织扩张的关键参数，并确定了单层速度与可测量流变学参数的函数关系。我们的结果使我们能够讨论药物扰动对观察到的组织动力学的影响。
