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腹腔镜下对疑似子宫肌瘤进行动力粉碎术。

Laparoscopic power morcellation of presumed fibroids.

作者信息

Brolmann Hans A, Sizzi Ornella, Hehenkamp Wouter J, Rossetti Alfonso

机构信息

Department of Gynecology, VU University Medical Centre, Amsterdam, the Netherlands -

出版信息

Minerva Ginecol. 2016 Jun;68(3):352-63. Epub 2016 Jan 22.

Abstract

Uterine leiomyoma is a highly prevalent benign gynecologic neoplasm that affects women of reproductive age. Surgical procedures commonly employed to treat symptomatic uterine fibroids include myomectomy or total or sub-total hysterectomy. These procedures, when performed using minimally invasive techniques, reduce the risks of intraoperative and postoperative morbidity and mortality; however, in order to remove bulky lesions from the abdominal cavity through laparoscopic ports, a laparoscopic power morcellator must be used, a device with rapidly spinning blades to cut the uterine tissue into fragments so that it can be removed through a small incision. Although the minimal invasive approach in gynecological surgery has been firmly established now in terms of recovery and quality of life, morcellation is associated with rare but sometimes serious adverse events. Parts of the morcellated specimen may be spread into the abdominal cavity and enable implantation of cells on the peritoneum. In case of unexpected sarcoma the dissemination may upstage disease and affect survival. Myoma cells may give rise to 'parasitic' fibroids, but also implantation of adenomyotic cells and endometriosis has been reported. Finally the morcellation device may cause inadvertent injury to internal structures, such as bowel and vessels, with its rotating circular knife. In this article it is described how to estimate the risk of sarcoma in a presumed fibroid based on epidemiologic, imaging and laboratory data. Furthermore the first literature results of the in-bag morcellation are reviewed. With this procedure the specimen is contained in an insufflated sterile bag while being morcellated, potentially preventing spillage of tissue but also making direct morcellation injuries unlikely to happen.

摘要

子宫平滑肌瘤是一种高度常见的良性妇科肿瘤,影响育龄女性。常用于治疗有症状的子宫肌瘤的外科手术包括肌瘤切除术或全子宫切除术或次全子宫切除术。这些手术采用微创技术进行时,可降低术中和术后发病及死亡风险;然而,为了通过腹腔镜端口从腹腔中取出较大的病变组织,必须使用腹腔镜动力粉碎器,这是一种带有快速旋转刀片的设备,可将子宫组织切成碎片,以便通过小切口取出。尽管妇科手术中的微创方法目前在恢复和生活质量方面已得到牢固确立,但粉碎术会伴有罕见但有时严重的不良事件。粉碎标本的部分组织可能会扩散到腹腔,使细胞在腹膜上着床。如果意外发现肉瘤,这种播散可能会使疾病分期升高并影响生存。肌瘤细胞可能会引发“寄生性”肌瘤,也有报道称会出现腺肌病细胞和子宫内膜异位症的着床。最后,粉碎设备的旋转圆刀可能会意外损伤内部结构,如肠道和血管。本文描述了如何根据流行病学、影像学和实验室数据评估疑似肌瘤中肉瘤的风险。此外,还回顾了袋内粉碎术的首批文献结果。通过这种方法,标本在粉碎时被置于充气的无菌袋中,有可能防止组织溢出,也不太可能发生直接的粉碎损伤。

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