Zhang Yan, Gauthier Susan A, Gupta Ajay, Comunale Joseph, Chia-Yi Chiang Gloria, Zhou Dong, Chen Weiwei, Giambrone Ashley E, Zhu Wenzhen, Wang Yi
Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Department of Neurology, Weill Cornell Medical College, New York, New York, USA.
J Magn Reson Imaging. 2016 Aug;44(2):426-32. doi: 10.1002/jmri.25144. Epub 2016 Jan 22.
To measure the longitudinal change in multiple sclerosis (MS) lesion susceptibility using quantitative susceptibility mapping (QSM).
The study was approved by our Institutional Review Board. Longitudinal changes in quantitative susceptibility values of new enhanced-with-Gd MS lesions were measured at baseline magnetic resonance imaging (MRI) and on a follow-up MRI in 29 patients within 2 years using a 3D multiple echo gradient echo sequence on a 3T scanner. Paired t-test and the generalized estimating equations (GEE) model was used to analyze the longitudinal change.
Lesion susceptibility values relative to normal-appearing white matter (NAWM) changed from 3.61 ± 6.11 ppb when enhanced-with-Gd at the baseline MRI to 20.42 ± 10.23 ppb when not-enhanced-with-Gd at the follow-up MRI (P < 0.001).
MS lesion susceptibility value increases significantly as the lesion evolves from enhanced-with-Gd to not-enhanced-with-Gd, serving as a disease biomarker. J. Magn. Reson. Imaging 2016;44:426-432.
使用定量磁化率成像（QSM）测量多发性硬化症（MS）病灶磁化率的纵向变化。
本研究经机构审查委员会批准。在29例患者中，于基线磁共振成像（MRI）时及2年内的随访MRI时，使用3T扫描仪上的三维多回波梯度回波序列测量新出现的钆增强MS病灶的定量磁化率值的纵向变化。采用配对t检验和广义估计方程（GEE）模型分析纵向变化。
相对于正常外观白质（NAWM）的病灶磁化率值，在基线MRI钆增强时为3.61±6.11 ppb，在随访MRI未钆增强时变为20.42±10.23 ppb（P<0.001）。
随着病灶从钆增强演变为未钆增强，MS病灶磁化率值显著增加，可作为一种疾病生物标志物。《磁共振成像杂志》2016年；44：426 - 432。
