Lorenzen Emma, Agerholm Jørgen Steen, Grossi Anette Blak, Bojesen Anders Miki, Skytte Christina, Erneholm Karin, Follmann Frank, Jungersen Gregers
Veterinary Reproduction and Obstetrics, Department of Large Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlægevej 68, 1870 Frederiksberg C, Copenhagen, Denmark; Chlamydia Vaccine Research, Department of Infectious Disease Immunology, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark.
Veterinary Reproduction and Obstetrics, Department of Large Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlægevej 68, 1870 Frederiksberg C, Copenhagen, Denmark.
Dev Comp Immunol. 2016 Jun;59:57-62. doi: 10.1016/j.dci.2016.01.006. Epub 2016 Jan 20.
The pig is increasingly used as an advanced animal model of the genital tract in women and knowledge on the genital immune system is therefore needed. In this study, evaluation of vaginal smears revealed that almost no neutrophils or other leukocytes were present in the vaginal mucosa of prepubertal minipigs (n = 10). In sexually mature minipigs (n = 10), evaluated through an estrous cycle, there was an increase in number of mucosal neutrophils and other leukocytes during estrus. The level of total IgA on the vaginal mucosa increased during diestrus. The level of total IgG showed no significant changes through the cycle. The vaginal IgA level in the prepubertal minipigs was similar to the low estrus level in sexually mature minipigs, and the IgG level in prepubertal was similar to the stable level in the sexually mature minipigs.
猪越来越多地被用作女性生殖道的高级动物模型，因此需要了解生殖道免疫系统。在本研究中，对阴道涂片的评估显示，青春期前小型猪（n = 10）的阴道黏膜中几乎没有中性粒细胞或其他白细胞。在通过发情周期评估的性成熟小型猪（n = 10）中，发情期黏膜中性粒细胞和其他白细胞的数量增加。阴道黏膜上总IgA水平在间情期升高。总IgG水平在整个周期中无显著变化。青春期前小型猪的阴道IgA水平与性成熟小型猪的低发情期水平相似，青春期前的IgG水平与性成熟小型猪的稳定水平相似。
