Izawa Kazuhiro P, Watanabe Satoshi, Oka Koichiro, Kasahara Yusuke, Morio Yuji, Hiraki Koji, Hirano Yasuyuki, Omori Yutaka, Suzuki Norio, Kida Keisuke, Suzuki Kengo, Akashi Yoshihiro J
Graduate School of Health Sciences, Kobe University, 10-2 Tomogaoka 7-chome Suma, Kobe, 654-0142, Japan.
Department of Rehabilitation Medicine, St. Marianna University School of Medicine Hospital, Kawasaki, Japan.
Aging Clin Exp Res. 2016 Dec;28(6):1143-1148. doi: 10.1007/s40520-016-0534-5. Epub 2016 Jan 22.
Little information exists on the relation between respiratory muscle strength such as maximum inspiratory muscle pressure (MIP) and sarcopenia in elderly cardiac patients. The present study aimed to determine the differences in MIP, and cutoff values for MIP according to sarcopenia in elderly cardiac patients.
We enrolled 63 consecutive elderly male patients aged ≥65 years with cardiac disease in this cross-sectional study. Sarcopenia was defined based on the European Working Group on Sarcopenia in Older People algorithm, and, accordingly, the patients were divided into two groups: the sarcopenia group (n = 24) and non-sarcopenia group (n = 39). The prevalence of sarcopenia in cardiac patients and MIP in the patients with and without sarcopenia were assessed to determine cutoff values of MIP.
After adjustment for body mass index, the MIP in the sarcopenia group was significantly lower than that in the non-sarcopenia group (54.7 ± 36.8 cmHO; 95 % CI 42.5-72.6 vs. 80.7 ± 34.7 cmHO; 95 % CI 69.5-92.0; F = 4.89, p = 0.029). A receiver-operating characteristic curve analysis of patients with and without sarcopenia identified a cutoff value for MIP of 55.6 cmHO, with a sensitivity of 0.76, 1-specificity of 0.37, and AUC of 0.70 (95 % CI 0.56-0.83; p = 0.01) in the study patients.
Compared with elderly cardiac patients without sarcopenia, MIP in those with sarcopenia may be negatively affected. The MIP cutoff value reported here may be a useful minimum target value for identifying elderly male cardiac patients with sarcopenia.
关于老年心脏病患者呼吸肌力量（如最大吸气肌压力，MIP）与肌肉减少症之间的关系，目前所知甚少。本研究旨在确定老年心脏病患者MIP的差异以及根据肌肉减少症划分的MIP临界值。
在这项横断面研究中，我们连续纳入了63例年龄≥65岁的老年男性心脏病患者。根据欧洲老年人肌肉减少症工作组的算法定义肌肉减少症，并据此将患者分为两组：肌肉减少症组（n = 24）和非肌肉减少症组（n = 39）。评估心脏病患者中肌肉减少症的患病率以及有和无肌肉减少症患者的MIP，以确定MIP的临界值。
在调整体重指数后，肌肉减少症组的MIP显著低于非肌肉减少症组（54.7±36.8cmH₂O；95%CI 42.5 - 72.6 vs. 80.7±34.7cmH₂O；95%CI 69.5 - 92.0；F = 4.89，p = 0.029）。对有和无肌肉减少症患者进行的受试者工作特征曲线分析确定，研究患者中MIP的临界值为55.6cmH₂O，敏感性为0.76，1-特异性为0.37，曲线下面积为0.70（"95%CI 0.56 - 0.83；p = 0.01"）。
与无肌肉减少症的老年心脏病患者相比，有肌肉减少症患者的MIP可能受到负面影响。此处报告的MIP临界值可能是识别患有肌肉减少症的老年男性心脏病患者的有用最低目标值。
