白色念珠菌生物膜：形成、调控及分子机制
Candida albicans biofilms: development, regulation, and molecular mechanisms.
作者信息
Gulati Megha, Nobile Clarissa J
机构信息
Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, Merced, CA, USA.
Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, Merced, CA, USA.
出版信息
Microbes Infect. 2016 May;18(5):310-21. doi: 10.1016/j.micinf.2016.01.002. Epub 2016 Jan 22.
Abstract
A major virulence attribute of Candida albicans is its ability to form biofilms, densely packed communities of cells adhered to a surface. These biofilms are intrinsically resistant to conventional antifungal therapeutics, the host immune system, and other environmental factors, making biofilm-associated infections a significant clinical challenge. Here, we review current knowledge on the development, regulation, and molecular mechanisms of C. albicans biofilms.
摘要
白色念珠菌的一个主要毒力特性是其形成生物膜的能力，生物膜是附着在表面的细胞密集堆积群落。这些生物膜对传统抗真菌疗法、宿主免疫系统和其他环境因素具有内在抗性，使得与生物膜相关的感染成为一项重大临床挑战。在此，我们综述了关于白色念珠菌生物膜的形成、调控及分子机制的现有知识。
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