Huh Jimi, Choi Yoonseok, Woo Dong-Cheol, Seo Nieun, Kim Bohyun, Lee Chang Kyung, Kim In Seong, Nickel Dominik, Kim Kyung Won
Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Korea.
Bioimaging Center, Asan Institute for Life Sciences, Asan Medical Center, 88 Olympic-ro, Seoul, Korea.
Eur Radiol. 2016 Nov;26(11):3949-3956. doi: 10.1007/s00330-016-4209-6. Epub 2016 Jan 25.
To evaluate the feasibility of test-bolus dynamic contrast-enhanced (DCE) MRI with CAIPIRINHA-VIBE for pancreatic malignancies.
Thirty-two patients underwent DCE-MRI with CAIPIRINHA-VIBE after injection of 2 mL gadolinium. From the resulting time-intensity curve (TIC), we estimated the arterial (AP) and portal venous phase (PVP) scan timing for subsequent multiphasic MRI. DCE-MRI perfusion maps were generated, and perfusion parameters were calculated. The image quality was rated on a 5-point scale (1: poor, 5: excellent). Goodness-of-fit of the TIC was evaluated by Pearson's χ test.
Test-bolus DCE-MRIs with high temporal (3 s) and spatial resolution (1 × 1 × 4 mm) were acquired with good-quality perfusion maps of Ktrans and iAUC (mean score 4.313 ± 0.535 and 4.125 ± 0.554, respectively). The mean χ values for fitted TICs were 0.115 ± 0.082 for the pancreatic parenchyma and 0.784 ± 0.074 for pancreatic malignancies, indicating an acceptable goodness-of-fit. Test-bolus DCE-MRI was highly accurate in estimating the proper timing of AP (90.6 %) and PVP (100 %) of subsequent multiphasic MRI. Between pancreatic adenocarcinomas and neuroendocrine tumours, there were significant differences in the Ktrans (0.073 ± 0.058 vs. 0.308 ± 0.062, respectively; p = 0.007) and iAUC (1.501 ± 0.828 vs. 3.378 ± 0.378, respectively; p = 0.045).
Test-bolus DCE-MRI using CAIPIRINHA-VIBE is feasible for incorporating perfusion analysis of pancreatic tumours into routine multiphasic MRI.
• Test-bolus DCE-MRI using CAIPIRINHA-VIBE is feasible for perfusion analysis of pancreatic tumours. • CAIPIRINHA-VIBE enables DCE-MRI with high temporal and spatial resolution. • Test-bolus DCE-MRI is highly accurate in estimating the proper timing of multiphasic MRI.
评估采用CAIPIRINHA-VIBE技术的团注动态对比增强（DCE）MRI用于胰腺恶性肿瘤的可行性。
32例患者在注射2 mL钆剂后接受CAIPIRINHA-VIBE序列的DCE-MRI检查。根据所得的时间-强度曲线（TIC），我们估算了后续多期MRI的动脉期（AP）和门静脉期（PVP）扫描时间。生成DCE-MRI灌注图并计算灌注参数。图像质量按5分制评分（1分：差，5分：优）。通过Pearson卡方检验评估TIC的拟合优度。
获得了具有高时间分辨率（3秒）和空间分辨率（1×1×4 mm）的团注DCE-MRI图像，Ktrans和iAUC的灌注图质量良好（平均评分分别为4.313±0.535和4.125±0.554）。胰腺实质拟合TIC的平均卡方值为0.115±0.082，胰腺恶性肿瘤为0.784±0.074，表明拟合优度可接受。团注DCE-MRI在估算后续多期MRI的AP（90.6%）和PVP（100%）的合适时间方面高度准确。在胰腺腺癌和神经内分泌肿瘤之间，Ktrans（分别为0.073±0.058和0.308±0.062；p = 0.007）和iAUC（分别为1.501±0.828和3.378±0.378；p = 0.045）存在显著差异。
采用CAIPIRINHA-VIBE技术的团注DCE-MRI可将胰腺肿瘤的灌注分析纳入常规多期MRI检查中。
• 采用CAIPIRINHA-VIBE技术的团注DCE-MRI用于胰腺肿瘤灌注分析是可行的。• CAIPIRINHA-VIBE技术可实现具有高时间和空间分辨率的DCE-MRI。• 团注DCE-MRI在估算多期MRI的合适时间方面高度准确。
