Sugai Takuro, Suzuki Yutaro, Yamazaki Manabu, Shimoda Kazutaka, Mori Takao, Ozeki Yuji, Matsuda Hiroshi, Sugawara Norio, Yasui-Furukori Norio, Minami Yoshitake, Okamoto Kurefu, Sagae Toyoaki, Someya Toshiyuki
Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan; Japanese Society of Clinical Neuropsychopharmacology, Tokyo, Japan.
Japan Psychiatric Hospital Association, Tokyo, Japan.
Schizophr Res. 2016 Mar;171(1-3):68-73. doi: 10.1016/j.schres.2016.01.016. Epub 2016 Jan 22.
Patients with schizophrenia have a higher risk of metabolic syndrome (MetS). MetS prevalence varies with ethnicity. Although environmental factors, such as lack of physical activity and unbalanced diet, can lead to MetS, these may differ between outpatients and inpatients with schizophrenia. The Japanese mental health care system differs from that in other countries. However, few studies have investigated the prevalence of MetS in Japanese patients with schizophrenia. Therefore, we conducted a nationwide survey to clarify the prevalence of MetS in Japanese outpatients and inpatients with schizophrenia. We investigated the risk of MetS by questionnaire in 520 facilities for outpatients and 247 facilities for inpatients. There were 7655 outpatients and 15,461 inpatients with schizophrenia. MetS prevalence was based on the National Cholesterol Education Program Adult Treatment Panel III (ATP III-A) and the Japan Society for the Study of Obesity (JASSO). The overall MetS prevalence in outpatients using the ATP III-A definition was 34.2%, with 37.8% in men and 29.4% in women, compared with 13.0% in inpatients, with 12.3% in men and 13.9% in women. MetS prevalence in outpatients was approximately 2- to 3-fold higher than in inpatients. In conclusion, MetS prevalence in Japanese outpatients was approximately 3-fold higher than in inpatients. Therefore, we should pay more attention to the risk of physical disease in Japanese patients with schizophrenia, considering the difference in health characteristics between outpatients and inpatients.
精神分裂症患者患代谢综合征(MetS)的风险更高。MetS的患病率因种族而异。尽管缺乏体育活动和饮食不均衡等环境因素可导致MetS,但这些因素在精神分裂症门诊患者和住院患者中可能有所不同。日本的精神卫生保健系统与其他国家不同。然而,很少有研究调查日本精神分裂症患者中MetS的患病率。因此,我们进行了一项全国性调查,以明确日本精神分裂症门诊患者和住院患者中MetS的患病率。我们通过问卷调查了520家门诊机构和247家住院机构中MetS的风险。共有7655名精神分裂症门诊患者和15461名精神分裂症住院患者。MetS患病率基于美国国家胆固醇教育计划成人治疗小组第三次报告(ATP III-A)和日本肥胖研究学会(JASSO)的标准。采用ATP III-A定义,门诊患者的总体MetS患病率为34.2%,男性为37.8%,女性为29.4%;相比之下,住院患者的患病率为13.0%,男性为12.3%,女性为13.9%。门诊患者的MetS患病率比住院患者高出约2至3倍。总之,日本门诊精神分裂症患者的MetS患病率比住院患者高出约3倍。因此,考虑到门诊患者和住院患者健康特征的差异,我们应该更加关注日本精神分裂症患者身体疾病的风险。