Department of Chemical Engineering, C0400, The University of Texas at Austin, Austin, TX 78712, USA, Department of Biomedical Engineering, C0800, The University of Texas at Austin, Austin, TX 78712, USA, College of Pharmacy, C0400, The University of Texas at Austin, Austin, TX 78712, USA.
Regen Biomater. 2014 Nov;1(1):57-65. doi: 10.1093/rb/rbu006. Epub 2014 Oct 20.
Multi-responsive hydrogels, or 'intelligent' hydrogels that respond to more than one environmental stimulus, have demonstrated great utility as a regenerative biomaterial in recent years. They are structured biocompatible materials that provide specific and distinct responses to varied physiological or externally applied stimuli. As evidenced by a burgeoning number of investigators, multi-responsive hydrogels are endowed with tunable, controllable and even biomimetic behavior well-suited for drug delivery and tissue engineering or regenerative growth applications. This article encompasses recent developments and challenges regarding supramolecular, layer-by-layer assembled and covalently cross-linked multi-responsive hydrogel networks and their application to drug delivery and tissue engineering.
近年来，多重响应水凝胶（即能够响应多种环境刺激的“智能”水凝胶）已作为一种再生生物材料显示出巨大的应用潜力。它们是结构生物相容性材料，对各种生理或外部施加的刺激具有特定而独特的响应。越来越多的研究人员证明，多重响应水凝胶具有可调、可控甚至仿生行为，非常适合药物输送和组织工程或再生生长应用。本文涵盖了关于超分子、层层组装和共价交联的多重响应水凝胶网络的最新进展和挑战，以及它们在药物输送和组织工程中的应用。
