Oe Mariko, Tashiro Toshiyuki, Yoshida Hideto, Nishiyama Hiroshi, Masuda Yasunobu, Maruyama Koh, Koikeda Takashi, Maruya Reiko, Fukui Naoshi
R&D Division, Kewpie Corporation, 2-5-7, Sengawa-cho, Chofu-shi, Tokyo, Japan.
Tokyo Yamate Medical Center, 3-22-1 Hyakunin-cho, Shinjyuku-ku, Tokyo, Japan.
Nutr J. 2016 Jan 27;15:11. doi: 10.1186/s12937-016-0128-2.
Hyaluronan (HA) is a component that is particularly abundant in the synovial fluid. Randomized, double-blinded, placebo-controlled trials carried out between 2008 and 2015 have proven the effectiveness of HA for the treatment of symptoms associated with synovitis, and particularly, knee pain, relief of synovial effusion or inflammation, and improvement of muscular knee strength. The mechanism by which HA exerts its effects in the living body, specifically receptor binding in the intestinal epithelia, has gradually been clarified. This review examines the effects of HA upon knee pain as assessed in clinical trials, as well as the mechanism of these effects and the safety of HA.
透明质酸（HA）是滑液中特别丰富的一种成分。2008年至2015年间进行的随机、双盲、安慰剂对照试验已证明HA对治疗与滑膜炎相关的症状有效，特别是膝痛、缓解滑膜积液或炎症以及改善膝关节肌肉力量。HA在生物体内发挥作用的机制，特别是在肠上皮细胞中的受体结合，已逐渐得到阐明。本综述研究了临床试验中评估的HA对膝痛的影响、这些影响的机制以及HA的安全性。
