Kumano Shun, Sugiyama Masuyuki, Yamada Masuyoshi, Nishimura Kazushige, Hasegawa Hideki, Morokuma Hidetoshi, Inoue Hiroyuki, Hashimoto Yuichiro
Hitachi, Ltd., Central Research Laboratory.
Hitachi High-Technologies Corp.
Mass Spectrom (Tokyo). 2015;4(1):A0038. doi: 10.5702/massspectrometry.A0038. Epub 2015 Apr 25.
We previously reported on the development of a portable mass spectrometer for the onsite screening of illicit drugs, but our previous sampling system could only be used for liquid samples. In this study, we report on an attempt to develop a probe heating method that also permits solid samples to be analyzed using a portable mass spectrometer. An aluminum rod is used as the sampling probe. The powdered sample is affixed to the sampling probe or a droplet of sample solution is placed on the tip of the probe and dried. The probe is then placed on a heater to vaporize the sample. The vapor is then introduced into the portable mass spectrometer and analyzed. With the heater temperature set to 130°C, the developed system detected 1 ng of methamphetamine, 1 ng of amphetamine, 3 ng of 3,4-methylenedioxymethamphetamine, 1 ng of 3,4-methylenedioxyamphetamine, and 0.3 ng of cocaine. Even from mixtures consisting of clove powder and methamphetamine powder, methamphetamine ions were detected by tandem mass spectrometry. The developed probe heating method provides a simple method for the analysis of solid samples. A portable mass spectrometer incorporating this method would thus be useful for the onsite screening of illicit drugs.
我们之前报道了一种用于现场筛查非法药物的便携式质谱仪的研发情况，但我们之前的采样系统仅能用于液体样品。在本研究中，我们报告了一种尝试开发的探针加热方法，该方法还允许使用便携式质谱仪对固体样品进行分析。使用一根铝棒作为采样探针。将粉末状样品附着在采样探针上，或者将一滴样品溶液放置在探针尖端并干燥。然后将探针置于加热器上以蒸发样品。接着将蒸汽引入便携式质谱仪进行分析。将加热器温度设定为130°C时，所开发的系统检测到1纳克甲基苯丙胺、1纳克苯丙胺、3纳克3,4-亚甲基二氧基甲基苯丙胺、1纳克3,4-亚甲基二氧基苯丙胺以及0.3纳克可卡因。即使是由丁香粉和甲基苯丙胺粉末组成的混合物，通过串联质谱法也能检测到甲基苯丙胺离子。所开发的探针加热方法为固体样品的分析提供了一种简单方法。因此，采用这种方法的便携式质谱仪将有助于现场筛查非法药物。
