Markway E Claire, Baker Stephanie N
Department of Pharmacy Services, University of Kentucky, Lexington, Kentucky, USA.
Orthopedics. 2011 Nov;34(11):877-81. doi: 10.3928/01477447-20110922-22.
Toxicology screens are used to detect the presence of prescription, nonprescription, or illicit substances. These tests are used in emergency situations to detect intentional or accidental overdose, to monitor drug dependency, and to screen for medical or legal purposes. An initial immunoassay reports qualitative results based on established cut-off concentrations. As a screening test, the initial immunoassay is less sensitive and therefore must be interpreted in the context of confounding variables such as the testing method, the substance being screened, and patient-specific characteristics. Either gas chromatography or high-performance liquid chromatography can be used to confirm positive results.
毒理学筛查用于检测处方药物、非处方药物或非法药物的存在。这些检测用于紧急情况，以检测故意或意外过量用药、监测药物依赖性，并用于医疗或法律目的的筛查。初始免疫分析根据既定的临界浓度报告定性结果。作为一种筛查测试，初始免疫分析的灵敏度较低，因此必须在诸如检测方法、被筛查物质和患者特定特征等混杂变量的背景下进行解释。气相色谱法或高效液相色谱法均可用于确认阳性结果。
