Dériaz O, Nacht C A, Chioléro R, Jéquier E, Acheson K J
Department of Anesthesiology, University Lausanne, Switzerland.
Metabolism. 1989 Nov;38(11):1082-8. doi: 10.1016/0026-0495(89)90044-9.
The thermic effect of glucose/insulin infusions was investigated in seven healthy young men before and during either inhibition (atropine sulphate 10 micrograms/kg bolus; 10 micrograms/kg/h) or stimulation (edrophonium chloride, 10 mg bolus; 0.75 mg/min starting rate) of the parasympathetic nervous system. The thermic effects of glucose/insulin were 6.2% +/- 0.4% and 5.6% +/- 0.7% before atropine and edrophonium, respectively, and increased to 7.1% +/- 0.5% (NS) with atropine and 7.5% +/- 1.2% (P less than .05) with edrophonium. In four subjects atropine or edrophonium was infused before the hyperinsulinemic, euglycemic clamp. A significant increase in resting metabolic rate and plasma norepinephrine concentrations was observed with edrophonium alone. When the thermic effects of glucose/insulin were calculated with respect to the metabolic rates observed during the drug infusions alone, they were 5.9% +/- 1.4% and 3.6% +/- 0.6% (NS) for the clamp + atropine and clamp + edrophonium, respectively. These results demonstrate that the increases in the thermic effect of glucose/insulin infusions observed during inhibition or stimulation of the parasympathetic nervous system were due to atropine or edrophonium increasing the resting metabolic rate rather than increasing the thermic response to glucose-insulin infusions. However, because it has been shown that atropine can decrease the thermic effect of an orally administered meal by approximately 60%, it would appear that the parasympathetic nervous system can influence the thermic effect of food by affecting the rate of digestion, absorption and storage of the ingested nutrients.
在七名健康年轻男性中，研究了在抑制（硫酸阿托品10微克/千克推注；10微克/千克/小时）或刺激（氯化腾喜龙，10毫克推注；起始速率0.75毫克/分钟）副交感神经系统之前和期间葡萄糖/胰岛素输注的热效应。在使用阿托品和氯化腾喜龙之前，葡萄糖/胰岛素的热效应分别为6.2%±0.4%和5.6%±0.7%，使用阿托品时增加到7.1%±0.5%（无统计学意义），使用氯化腾喜龙时增加到7.5%±1.2%（P<0.05）。在四名受试者中，在高胰岛素正常血糖钳夹之前输注阿托品或氯化腾喜龙。单独使用氯化腾喜龙时，静息代谢率和血浆去甲肾上腺素浓度显著增加。当根据单独药物输注期间观察到的代谢率计算葡萄糖/胰岛素的热效应时，钳夹+阿托品组和钳夹+氯化腾喜龙组分别为5.9%±1.4%和3.6%±0.6%（无统计学意义）。这些结果表明，在副交感神经系统抑制或刺激期间观察到的葡萄糖/胰岛素输注热效应增加是由于阿托品或氯化腾喜龙增加了静息代谢率，而不是增加了对葡萄糖-胰岛素输注的热反应。然而，由于已经表明阿托品可以使口服餐食的热效应降低约60%，因此似乎副交感神经系统可以通过影响摄入营养物质的消化、吸收和储存速率来影响食物的热效应。
