Gill Balraj Singh, Alex Jimi Marin, Kumar Sanjeev
Centre for Biosciences, School of Basic and Applied Sciences, Central University of Punjab, Bathinda, 151001, India.
Centre for Chemical and Pharmaceutical Sciences, School of Basic and Applied Sciences, Central University of Punjab, Bathinda, 151001, India.
Tumour Biol. 2016 May;37(5):5683-704. doi: 10.1007/s13277-016-4900-x. Epub 2016 Jan 28.
MicroRNAs are the non-coding RNAs which regulate endogenous gene expression in animal and plant cells. Alterations in the level of micro-ribonucleic acids (miRNAs) involving the deletions, overexpression, mutations, epigenetic silencing, or dysregulation of transcription factors that target specific miRNAs may culminate in various diseases including cancer. Recent findings demonstrate the role of miRNAs in prostate cancer. Numerous discoveries of miRNAs have marked the research and development surrounding prostate cancer management, diagnosis, and therapy which has made prediction easy, but the effective treatment strategy remains a mystery. This review seeks to draw a link between miRNA and prostate cancer through an understanding of the numerous signaling pathways that these miRNAs control, which may prove to be helpful in identifying therapeutically interesting molecular targets.
微小RNA是在动植物细胞中调节内源性基因表达的非编码RNA。微小核糖核酸（miRNA）水平的改变，包括缺失、过表达、突变、表观遗传沉默或靶向特定miRNA的转录因子失调，可能导致包括癌症在内的各种疾病。最近的研究结果表明了miRNA在前列腺癌中的作用。miRNA的众多发现标志着围绕前列腺癌管理、诊断和治疗的研究与开发，这使得预测变得容易，但有效的治疗策略仍然是个谜。本综述旨在通过了解这些miRNA所控制的众多信号通路，来建立miRNA与前列腺癌之间的联系，这可能有助于识别具有治疗意义的分子靶点。
