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肥胖与机器人辅助手术期间肺顺应性降低和高碳酸血症有关。

Obesity is associated with decreased lung compliance and hypercapnia during robotic assisted surgery.

作者信息

Tomescu Dana Rodica, Popescu Mihai, Dima Simona Olimpia, Bacalbașa Nicolae, Bubenek-Turconi Șerban

机构信息

Department of Anesthesiology and Critical Care III, Fundeni Clinical Institute, 258 Fundeni Street, 2nd District, Bucharest, 022328, Romania.

"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

出版信息

J Clin Monit Comput. 2017 Feb;31(1):85-92. doi: 10.1007/s10877-016-9831-y. Epub 2016 Jan 28.

Abstract

Robotic assisted surgery (RAS) represents a great challenge for anesthesiology due to the increased intraabdomial pressures required for surgical optimal approach. The changes in lung physiology are difficult to predict and require fast decision making in order to prevent altered gas exchange. The aim of this study was to document the combined effect of patient physical status, medical history and intraoperative position during RAS on lung physiology and to determine perioperative risk factors for hypercapnia. We prospectively analyzed 62 patients who underwent elective RAS. Age, co-morbidities and body mass index (BMI) were recorded before surgery. Ventilatory parameters and arterial blood gas analysis were determined before induction of anesthesia, after tracheal intubation and on an hourly basis until the end of surgery. In RAS, the induction of pneumoperitoneum was associated with a significant decrease in lung compliance from a mean of 42.5-26.7 ml cm HO (p = 0.001) and an increase in plateau pressure from a mean of 16.1 mmHg to a mean of 23.6 mmHg (p = 0.001). Obesity, demonstrated by a BMI over 30, significantly correlates with a decrease in lung compliance after induction of anesthesia (p = 0.001). A significant higher increase in arterial CO tension was registered in patients undergoing RAS in steep Trendelenburg position (p = 0.05), but no significant changes in end-tidal CO were recorded. A higher arterial to end-tidal CO tension gradient was observed in patients with a BMI > 30 (p < 0.001). In conclusion, patients' physical status, especially obesity, represents the main risk factor for decreased lung compliance during RAS and patient positioning in either Trendelenburg or steep Trendelenburg during surgery has limited effects on respiratory physiology.

摘要

由于手术最佳入路需要增加腹腔内压力,机器人辅助手术(RAS)对麻醉学来说是一项巨大挑战。肺部生理变化难以预测,需要快速做出决策以防止气体交换改变。本研究的目的是记录RAS期间患者身体状况、病史和术中体位对肺部生理的综合影响,并确定围手术期高碳酸血症的危险因素。我们前瞻性分析了62例行择期RAS的患者。术前记录年龄、合并症和体重指数(BMI)。在麻醉诱导前、气管插管后以及每小时直至手术结束时测定通气参数和动脉血气分析。在RAS中,气腹的诱导与肺顺应性显著降低相关,从平均42.5 ml/cm H₂O降至26.7 ml/cm H₂O(p = 0.001),平台压从平均16.1 mmHg升至平均23.6 mmHg(p = 0.001)。BMI超过30所显示的肥胖与麻醉诱导后肺顺应性降低显著相关(p = 0.001)。处于陡峭头低脚高位接受RAS的患者动脉血二氧化碳张力显著升高(p = 0.05),但呼气末二氧化碳无显著变化。BMI > 30的患者观察到动脉血与呼气末二氧化碳张力梯度更高(p < 0.001)。总之,患者的身体状况,尤其是肥胖,是RAS期间肺顺应性降低的主要危险因素,手术期间患者处于头低脚位或陡峭头低脚位对呼吸生理的影响有限。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4339/5253149/01c47c3bb3bc/10877_2016_9831_Fig1_HTML.jpg

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