du Plooy Christine Susara, Mels Catharina Martha Cornelia, Huisman Hugo Willem, Kruger Ruan
Hypertension in Africa Research Team (HART), North-West University, Potchefstroom 2531, South Africa.
Hypertension in Africa Research Team (HART), North-West University, Potchefstroom 2531, South Africa; Medical Research Council, Research Unit for Hypertension and Cardiovascular Disease, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.
J Amino Acids. 2015;2015:481517. doi: 10.1155/2015/481517. Epub 2015 Dec 28.
Background. Limited data exist regarding endothelin-1 (ET-1), a vasoactive contributor in vascular tone, in a population subjected to early vascular deterioration. We compared ET-1 levels and explored its association with markers of arterial stiffness in black and white South Africans. Methodology. This cross-sectional substudy included 195 black (men: n = 99; women: n = 95) and 197 white (men: n = 99; women: n = 98) South Africans. Serum ET-1 levels were measured as well as markers of arterial stiffness (blood pressure, pulse wave velocity, and arterial compliance). ET-1 levels were higher in black men and white women compared to their counterparts after adjusting for C-reactive protein. In both single and partial (adjusting for body mass index and gamma glutamyl transferase) regression analyses ET-1 correlated with age, interleukin-6, high density lipoprotein cholesterol, systolic blood pressure, pulse pressure, and pulse wave velocity in black women. In multivariate regression analyses the independent association of ET-1 with systolic blood pressure (Adj. R (2) = 0.13; β = 0.28, p < 0.01) and pulse pressure (Adj. R (2) = 0.11; β = 0.27, p < 0.01) was confirmed in black women only. ET-1 additionally associated with interleukin-6 in black women (p < 0.01). Conclusion. Our result suggests that ET-1 and its link with subclinical arteriosclerosis are potentially driven by low-grade inflammation as depicted by the association with interleukin-6 in the black female cohort.
背景。关于内皮素-1（ET-1）这一血管张力中的血管活性因子，在早期血管恶化人群中的相关数据有限。我们比较了南非黑人和白人中ET-1水平，并探讨了其与动脉僵硬度标志物之间的关联。方法。这项横断面子研究纳入了195名南非黑人（男性：n = 99；女性：n = 95）和197名南非白人（男性：n = 99；女性：n = 98）。测量了血清ET-1水平以及动脉僵硬度标志物（血压、脉搏波速度和动脉顺应性）。在校正C反应蛋白后，黑人男性和白人女性的ET-1水平高于其相应性别对照组。在单因素和部分（校正体重指数和γ-谷氨酰转移酶）回归分析中，黑人女性的ET-1与年龄、白细胞介素-6、高密度脂蛋白胆固醇、收缩压、脉压和脉搏波速度相关。在多因素回归分析中，仅在黑人女性中证实了ET-1与收缩压（调整后R(2)=0.13；β = 0.28，p < 0.01）和脉压（调整后R(2)=0.11；β = 0.27，p < 0.01）的独立关联。此外，黑人女性的ET-1还与白细胞介素-6相关（p < 0.01）。结论。我们的结果表明，ET-1及其与亚临床动脉硬化的联系可能是由低度炎症驱动的，如黑人女性队列中与白细胞介素-6的关联所示。
