Alam Nur Haque, Ashraf Hasan, Kamruzzaman Mohammad, Ahmed Tahmeed, Islam Sufia, Olesen Maryam Kadjar, Gyr Niklaus, Meier Remy
International Centre for Diarrheal Disease Research Bangladesh (icddr,b), Dhaka, Bangladesh.
Department of Pharmacy, East West University, Dhaka, Bangladesh.
J Health Popul Nutr. 2015 May 1;34:3. doi: 10.1186/s41043-015-0003-3.
To examine whether PHGG added ORS reduce duration of diarrhoea, stool output and enhance weight gain.
In a double-blind controlled clinical trial, 126 malnourished children (weight for length/weight for age < -3 Z-score with or without pedal edema), aged 6 - 36 months with acute diarrhoea <7 days were studied in two treatment groups; 63 received modified WHO ORS (Na 75, K 40, Cl 87, citrate 7, glucose 90 mmol/L) with PHGG 15 g/L (study group); 63 received modified WHO ORS without PHGG (control). Other treatments were similar in both groups. The study protocol was approved by Ethics Committee of icddr,b; the study was carried out at the Dhaka Hospital.
The mean duration of diarrhoea (h) was significantly shorter in children of the study group (Study vs. control, mean ± SD, 57 ± 31 vs. 75 ± 39, p = 0.01). Although there was a trend in stool weight reduction in children receiving ORS with PHGG (study vs. control, stool weight (g), mean ± SD; 1(st) 24 hour, 854.03 ± 532.15 vs. 949.11 ± 544.33, p = 0.32; 2(nd) 24 hour, 579.84 ± 466.01 vs. 761.26 ± 631.64, p = 0.069; 3(rd) 24 hour, 385.87 ± 454.09 vs. 495.73 ± 487.61, p = 0.196), especially in 2(nd) 24 h period, the difference was not statistically significant. The mean time (day) to attain weight for length 80% of NCHS median without edema was significantly shorter in the study group (study vs. control, mean ± SD, 4.5 ± 2.6 vs. 5.7 ± 2.8, p = 0.027).
PHGG added to ORS substantially reduced duration of diarrhoea. It also enhanced weight gain. Further studies might substantiate to establish its beneficial effect.
NCT01821586.
研究添加聚葡萄糖的口服补液盐（PHGG-ORS）是否能缩短腹泻持续时间、减少粪便排出量并促进体重增加。
在一项双盲对照临床试验中，将126名年龄在6至36个月、患有急性腹泻且病程小于7天的营养不良儿童（身长别体重/年龄别体重＜-3 Z评分，有或无足部水肿）分为两个治疗组进行研究；63名儿童接受添加了15 g/L聚葡萄糖的改良世界卫生组织口服补液盐（Na 75、K 40、Cl 87、柠檬酸盐7、葡萄糖90 mmol/L）（研究组）；63名儿童接受未添加聚葡萄糖的改良世界卫生组织口服补液盐（对照组）。两组的其他治疗方法相似。该研究方案经孟加拉腹泻病研究国际中心伦理委员会批准；研究在达卡医院进行。
研究组儿童的腹泻平均持续时间（小时）明显更短（研究组与对照组，均值±标准差，57±31 vs. 75±39，p = 0.01）。尽管接受添加聚葡萄糖口服补液盐的儿童粪便重量有减轻趋势（研究组与对照组，粪便重量（克），均值±标准差；第1个24小时，854.03±532.15 vs. 949.11±544.33，p = 0.32；第2个24小时，579.84±466.01 vs. 761.26±631.64，p = 0.069；第3个24小时，385.87±454.09 vs. 495.73±487.61，p = 0.196），尤其是在第2个24小时期间，但差异无统计学意义。研究组达到身长别体重为美国国家卫生统计中心中位数80%且无水肿的平均时间（天）明显更短（研究组与对照组，均值±标准差，4.5±2.6 vs. 5.7±2.8，p = 0.027）。
添加聚葡萄糖的口服补液盐可显著缩短腹泻持续时间，还能促进体重增加。进一步研究可能会证实其有益效果。
NCT01821586。
