Yan Wanjun, Ma Xingcong, Gao Xiaoyan, Zhang Shuqun
From the Department of Oncology, the Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China.
Medicine (Baltimore). 2016 Jan;95(4):e2566. doi: 10.1097/MD.0000000000002566.
Leptin is a confirmed breast cancer susceptibility gene. However, published studies reported mixed results. This meta-analysis was conducted to systematically get a more accurate estimation of the association between the Leptin (-2548G/A) gene polymorphism and breast cancer risk. To assess the effect of Leptin (-2548G/A) gene polymorphism on breast cancer susceptibility, we searched PUBMED, ISI Web of Knowledge, EMBASE, Chinese National Knowledge Infrastructure (CNKI) databases until September 2015 to identify eligible studies, without restriction. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the susceptibility to breast cancer. Separate analyses were conducted on features of the population such as ethnicity, source of controls, and country. A total of 9 case-control studies on Leptin (-2548G/A) gene polymorphism and breast cancer risk, including 3725 cases and 3093 case-free controls were identified. The results revealed that compared with the G allele, the A allele was associated with modestly increased risk of overall breast cancer (A vs G: OR = 1.12, 95%CI = 1.04-1.20, P = 0.002, Phet P < 0.00001). Following further stratified analyses, in the subgroup analyses by ethnicity, a significantly increased risk was observed among Caucasian (A vs G: OR = 1.11, 95%CI = 1.03-1.20, P = 0.006, Phet = 0.00001). No publication bias was found in the present study. In conclusion, our meta-analysis suggests that the Leptin (-2548G/A) gene polymorphism plays an important role in breast cancer susceptibility, especially in Caucasian.
瘦素是一种已被确认的乳腺癌易感基因。然而，已发表的研究报告结果不一。本荟萃分析旨在系统地更准确估计瘦素（-2548G/A）基因多态性与乳腺癌风险之间的关联。为评估瘦素（-2548G/A）基因多态性对乳腺癌易感性的影响，我们检索了截至2015年9月的PUBMED、科学网（ISI Web of Knowledge）、EMBASE、中国知网（CNKI）数据库，以识别符合条件的研究，无任何限制。汇总比值比（OR）和95%置信区间（CI）用于评估乳腺癌易感性。针对人群特征如种族、对照来源和国家进行了单独分析。共识别出9项关于瘦素（-2548G/A）基因多态性与乳腺癌风险的病例对照研究，包括3725例病例和3093例无病对照。结果显示，与G等位基因相比，A等位基因与总体乳腺癌风险适度增加相关（A vs G：OR = 1.12，95%CI = 1.04 - 1.20，P = 0.002，Phet P < 0.00001）。经过进一步分层分析，在按种族进行的亚组分析中，白种人中有显著增加的风险（A vs G：OR = 1.11，95%CI = 1.03 - 1.20，P = 0.006，Phet = 0.00001）。本研究未发现发表偏倚。总之，我们的荟萃分析表明，瘦素（-2548G/A）基因多态性在乳腺癌易感性中起重要作用，尤其是在白种人中。
