Akhavan Setareh, Safari Aghdas, Azizmohammadi Sima, Azizmohammadi Susan, Aslami Maysam, Yahaghi Emad, Seifoleslami Mehri
Department of Obstetrics and Gynecology, School of Medicine, Imam Khomeini Hospital Complex and Vali Asr Hospital, Oncology Ward, Tehran University of Medical Sciences, Tehran, Iran.
Department of Gynecology, Imam Reza Hospital, AJA University of Medical Sciences, Tehran, Iran.
Tumour Biol. 2016 Aug;37(8):10149-53. doi: 10.1007/s13277-016-4882-8. Epub 2016 Jan 29.
In this study, we evaluated mRNA expression levels of interleukin (IL)-10/IL-17A by quantitative real-time PCR and their clinical importance in cervical cancer. The IL-10 mRNA levels were higher in cervical cancer tissues as compared with corresponding normal tissues (p < 0.05). Moreover, IL-17A mRNA was significantly increased in cervical cancer tissues than in normal tissues (p < 0.05). Moreover, the high expression level of IL-10 mRNA was markedly related to International League of Gynecology and Obstetrics (FIGO) stage (p = 0.001), but no significant association was found with other clinical factors including age, tumor size, histological grades, and lymph node metastasis. Moreover, high expression levels of IL-17A were not associated with patients' age, tumor size, FIGO stage, and histological grades while IL-17A expression was strongly linked to lymphatic metastasis (p = 0.001). These findings showed that IL-17A might have a crucial role in cervical cancer metastasis. Taken together, IL-17A expression was strongly linked to lymphatic metastasis, indicating that IL-17A might have a crucial role in cervical cancer metastasis. Moreover, our study suggested the association of IL-10 mRNA expression with clinical stage.
在本研究中，我们通过定量实时聚合酶链反应评估了白细胞介素（IL）-10/IL-17A的信使核糖核酸（mRNA）表达水平及其在宫颈癌中的临床意义。与相应的正常组织相比，宫颈癌组织中的IL-10 mRNA水平更高（p<0.05）。此外，宫颈癌组织中的IL-17A mRNA比正常组织显著增加（p<0.05）。此外，IL-10 mRNA的高表达水平与国际妇产科联盟（FIGO）分期显著相关（p=0.001），但未发现与年龄、肿瘤大小、组织学分级和淋巴结转移等其他临床因素有显著关联。此外，IL-17A的高表达水平与患者年龄、肿瘤大小、FIGO分期和组织学分级无关，而IL-17A表达与淋巴转移密切相关（p=0.001）。这些发现表明，IL-17A可能在宫颈癌转移中起关键作用。综上所述，IL-17A表达与淋巴转移密切相关，表明IL-17A可能在宫颈癌转移中起关键作用。此外，我们的研究提示了IL-10 mRNA表达与临床分期的关联。
