Priyadharshini V S, Teran Luis M
Instituto Nacional de Enfemedades Respiratorias, Delegación Tlalpan, Mexico.
Instituto Nacional de Enfemedades Respiratorias, Delegación Tlalpan, Mexico.
Adv Protein Chem Struct Biol. 2016;102:115-46. doi: 10.1016/bs.apcsb.2015.11.008. Epub 2015 Dec 31.
Respiratory diseases affect humanity globally, with chronic lung diseases (e.g., asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, among others) and lung cancer causing extensive morbidity and mortality. These conditions are highly heterogeneous and require an early diagnosis. However, initial symptoms are nonspecific, and the clinical diagnosis is made late frequently. Over the last few years, personalized medicine has emerged as a medical care approach that uses novel technology aiming to personalize treatments according to the particular patient's medical needs. This review highlights the contributions of proteomics toward the understanding of personalized medicine in respiratory disease and its potential applications in the clinic.
呼吸系统疾病在全球范围内影响着人类，慢性肺部疾病（如哮喘、慢性阻塞性肺疾病、特发性肺纤维化等）和肺癌导致了广泛的发病和死亡。这些病症具有高度异质性，需要早期诊断。然而，初始症状不具有特异性，临床诊断常常较晚做出。在过去几年中，精准医学已成为一种医疗方法，它使用新技术旨在根据特定患者的医疗需求实现治疗的个性化。本综述强调了蛋白质组学在理解呼吸系统疾病精准医学方面的贡献及其在临床中的潜在应用。
