Effendi Wiwin Is, Nagano Tatsuya
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga (UNAIR), Surabaya 60132, Indonesia.
Department of Pulmonology and Respiratory Medicine, Universitas Airlangga Teaching Hospital, Surabaya 60015, Indonesia.
Biomedicines. 2023 Mar 28;11(4):1047. doi: 10.3390/biomedicines11041047.
Genetic information is not transmitted solely by DNA but by the epigenetics process. Epigenetics describes molecular missing link pathways that could bridge the gap between the genetic background and environmental risk factors that contribute to the pathogenesis of pulmonary fibrosis. Specific epigenetic patterns, especially DNA methylation, histone modifications, long non-coding, and microRNA (miRNAs), affect the endophenotypes underlying the development of idiopathic pulmonary fibrosis (IPF). Among all the epigenetic marks, DNA methylation modifications have been the most widely studied in IPF. This review summarizes the current knowledge concerning DNA methylation changes in pulmonary fibrosis and demonstrates a promising novel epigenetics-based precision medicine.
遗传信息并非仅由DNA传递，还通过表观遗传过程传递。表观遗传学描述了分子间的缺失环节途径，这些途径可以弥合遗传背景与导致肺纤维化发病机制的环境风险因素之间的差距。特定的表观遗传模式，尤其是DNA甲基化、组蛋白修饰、长链非编码RNA和微小RNA（miRNA），影响特发性肺纤维化（IPF）发展的内表型。在所有表观遗传标记中，DNA甲基化修饰在IPF中研究最为广泛。本综述总结了目前关于肺纤维化中DNA甲基化变化的知识，并展示了一种基于表观遗传学的有前景的新型精准医学。
