用于分析HIV持续性和根除的体内平台。
In vivo platforms for analysis of HIV persistence and eradication.
作者信息
Garcia J Victor
出版信息
J Clin Invest. 2016 Feb;126(2):424-31. doi: 10.1172/JCI80562. Epub 2016 Feb 1.
Abstract
HIV persistence in patients undergoing antiretroviral therapy is a major impediment to the cure of HIV/AIDS. The molecular and cellular mechanisms underlying HIV persistence in vivo have not been fully elucidated. This lack of basic knowledge has hindered progress in this area. The in vivo analysis of HIV persistence and the implementation of curative strategies would benefit from animal models that accurately recapitulate key aspects of the human condition. This Review summarizes the contribution that humanized mouse models of HIV infection have made to the field of HIV cure research. Even though these models have been shown to be highly informative in many specific areas, their great potential to serve as excellent platforms for discovery in HIV pathogenesis and treatment has yet to be fully developed.
摘要
接受抗逆转录病毒治疗的患者体内的HIV持续存在是治愈HIV/AIDS的主要障碍。HIV在体内持续存在的分子和细胞机制尚未完全阐明。这一基础知识的缺乏阻碍了该领域的进展。对HIV持续存在进行体内分析并实施治愈策略将受益于能够准确概括人类状况关键方面的动物模型。本综述总结了HIV感染人源化小鼠模型对HIV治愈研究领域的贡献。尽管这些模型在许多特定领域已被证明具有很高的信息量，但它们作为HIV发病机制和治疗发现的优秀平台的巨大潜力尚未得到充分开发。
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