Wang Ying, Jacobs Eric J, Newton Christina C, McCullough Marjorie L
Epidemiology Research Program, American Cancer Society, Atlanta, GA.
Int J Cancer. 2016 Jun 15;138(12):2846-55. doi: 10.1002/ijc.30027. Epub 2016 Feb 23.
While dietary lycopene and tomato products have been inversely associated with prostate cancer incidence, there is limited evidence for an association between consumption of lycopene and tomato products and prostate-cancer specific mortality (PCSM). We examined the associations of prediagnosis and postdiagnosis dietary lycopene and tomato product intake with PCSM in a large prospective cohort. This analysis included men diagnosed with nonmetastatic prostate cancer between enrollment in the Cancer Prevention Study II Nutrition Cohort in 1992 or 1993 and June 2011. Prediagnosis dietary data, collected at baseline, were available for 8,898 men, of whom 526 died of prostate cancer through 2012. Postdiagnosis dietary data, collected on follow-up surveys in 1999 and/or 2003, were available for 5,643 men, of whom 363 died of prostate cancer through 2012. Cox proportional hazards regression was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for PCSM. Neither prediagnosis nor postdiagnosis dietary lycopene intake was associated with PCSM (fourth vs. first quartile HR = 1.00, 95% CI 0.78-1.28; HR = 1.22, 95% CI 0.91-1.64, respectively). Similarly, neither prediagnosis nor postdiagnosis consumption of tomato products was associated with PCSM. Among men with high-risk cancers (T3-T4 or Gleason score 8-10, or nodal involvement), consistently reporting lycopene intake ≥ median on both postdiagnosis surveys was associated with lower PCSM (HR = 0.41, 95% CI 0.17-0.99, based on ten PCSM cases consistently ≥ median intake) compared to consistently reporting intake < median. Future studies are needed to confirm the potential inverse association of consistently high lycopene intake with PCSM among men with high-risk prostate cancers.
虽然膳食中的番茄红素和番茄制品与前列腺癌发病率呈负相关，但关于番茄红素和番茄制品的摄入量与前列腺癌特异性死亡率（PCSM）之间的关联，证据有限。我们在一个大型前瞻性队列中研究了诊断前和诊断后膳食中番茄红素和番茄制品的摄入量与PCSM的关联。该分析纳入了1992年或1993年参加癌症预防研究II营养队列至2011年6月期间被诊断为非转移性前列腺癌的男性。8898名男性有诊断前的基线膳食数据，其中526人在2012年前死于前列腺癌。5643名男性有诊断后的膳食数据，这些数据来自1999年和/或2003年的随访调查，其中363人在2012年前死于前列腺癌。采用Cox比例风险回归计算PCSM的风险比（HRs）和95%置信区间（CIs）。诊断前和诊断后的膳食番茄红素摄入量均与PCSM无关（第四分位数与第一分位数相比，HR = 1.00，95% CI 0.78 - 1.28；HR = 1.22，95% CI 0.91 - 1.64）。同样，诊断前和诊断后番茄制品的摄入量均与PCSM无关。在患有高危癌症（T3 - T4或Gleason评分8 - 10，或有淋巴结转移）的男性中，与始终报告摄入量低于中位数相比，在两次诊断后调查中均始终报告番茄红素摄入量≥中位数与较低的PCSM相关（基于10例始终≥中位数摄入量的PCSM病例，HR = 0.41，95% CI 0.17 - 0.99）。未来需要进行研究，以证实始终高摄入番茄红素与高危前列腺癌男性的PCSM之间潜在的负相关关系。
