Liu Zhenhua, Guo Jifeng, Wang Yaqin, Li Kai, Kang Jifeng, Wei Yang, Sun Qiying, Xu Qian, Xu Changshui, Yan Xinxiang, Tang Beisha
Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, People's Republic of China.
State Key Laboratory of Medical Genetics, Changsha, 410008 Hunan, People's Republic of China.
Sci Rep. 2016 Feb 2;6:19021. doi: 10.1038/srep19021.
Inflammatory processes have been implicated in the pathogenesis of Parkinson's disease (PD), including the development of PD-associated cognitive impairment. Whether genetic variants of inflammatory cytokine genes influence the risk of cognitive impairment in PD is unknown. In this study, we investigated single nucleotide polymorphisms (SNPs) in the IL-10 promoter (rs1800871 and rs1800872) and in the IL-18 promoter (rs1946518 and rs187238) in a Han Chinese cohort (N = 933). PD patients (N = 460) and controls (N = 473) were genotyped. Additionally, 268 PD patients were divided into three subgroups [cognitively normal (PD-NC), mild cognitive impairment (PD-MCI), and with dementia (PD-D)] on the basis of their performance on a battery of neuropsychological tests. No associations were found between the aforementioned polymorphisms and cognitive impairment in PD; thus no confirmatory evidence for the hypothesis of IL-10 and IL-18 alleles modulating the risk of cognitive impairment in Chinese PD patients was obtained.
炎症过程与帕金森病（PD）的发病机制有关，包括与PD相关的认知障碍的发展。炎性细胞因子基因的遗传变异是否会影响PD患者认知障碍的风险尚不清楚。在本研究中，我们在一个汉族队列（N = 933）中研究了白细胞介素-10（IL-10）启动子（rs1800871和rs1800872）以及白细胞介素-18（IL-18）启动子（rs1946518和rs187238）中的单核苷酸多态性（SNP）。对PD患者（N = 460）和对照组（N = 473）进行基因分型。此外，根据一系列神经心理学测试的表现，将268名PD患者分为三个亚组[认知正常（PD-NC）、轻度认知障碍（PD-MCI）和痴呆（PD-D）]。未发现上述多态性与PD患者的认知障碍之间存在关联；因此，未获得支持IL-10和IL-18等位基因调节中国PD患者认知障碍风险这一假设的确证性证据。
