Lau William W, Tsang John S
Office of Intramural Research, Center for Information Technology, National Institutes of Health, Bethesda, MD, USA.
Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Trends Immunol. 2016 Mar;37(3):167-169. doi: 10.1016/j.it.2016.01.003. Epub 2016 Jan 29.
In a recent study, Chung et al. report the development of a high-dimensional approach to assess humoral responses to immune perturbation that goes beyond antibody neutralization and titers. This approach enables the identification of potentially novel correlates and mechanisms of protective immunity to HIV vaccination, thus offering a glimpse of how dense phenotyping of serological responses coupled with bioinformatics analysis could lead to much-sought-after markers of protective vaccination responses.
在最近的一项研究中，钟等人报告了一种高维方法的进展，该方法用于评估对免疫扰动的体液反应，超越了抗体中和作用和滴度。这种方法能够识别针对HIV疫苗接种的保护性免疫的潜在新关联和机制，从而让我们初步了解血清学反应的密集表型分析与生物信息学分析相结合如何能够产生人们长期寻求的保护性疫苗接种反应标志物。
