过氧化物酶体增殖物激活受体概述。
Overview on Peroxiredoxin.
作者信息
Rhee Sue Goo
机构信息
Yonsei Biomedical Research Institute, Yonsei University College of Medicine, Seoul 120-752, Korea.
出版信息
Mol Cells. 2016 Jan;39(1):1-5. doi: 10.14348/molcells.2016.2368.
Abstract
Peroxiredoxins (Prxs) are a very large and highly conserved family of peroxidases that reduce peroxides, with a conserved cysteine residue, designated the "peroxidatic" Cys (CP) serving as the site of oxidation by peroxides (Hall et al., 2011; Rhee et al., 2012). Peroxides oxidize the CP-SH to cysteine sulfenic acid (CP-SOH), which then reacts with another cysteine residue, named the "resolving" Cys (CR) to form a disulfide that is subsequently reduced by an appropriate electron donor to complete a catalytic cycle. This overview summarizes the status of studies on Prxs and relates the following 10 minireviews.
摘要
过氧化物酶体增殖物激活受体（Prxs）是一个非常庞大且高度保守的过氧化物酶家族，可还原过氧化物，其具有一个保守的半胱氨酸残基，称为“过氧化物酶”半胱氨酸（CP），作为过氧化物氧化的位点（Hall等人，2011年；Rhee等人，2012年）。过氧化物将CP-SH氧化为半胱氨酸亚磺酸（CP-SOH），然后它与另一个半胱氨酸残基反应，称为“分解”半胱氨酸（CR），形成二硫键，随后由合适的电子供体将其还原以完成催化循环。本综述总结了关于Prxs的研究现状，并关联了以下10篇小型综述。
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