Wang Mengjie, Tao Ling, Xu Hongxi
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203 China ; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203 China.
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203 China ; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203 China ; Xinxiang Medical University, Jinsui Road 601, Xinxiang, Henan 453003 China.
Chin Med. 2016 Jan 28;11:2. doi: 10.1186/s13020-016-0074-0. eCollection 2016.
Enterovirus 71 (EV71) is one of the causative agents of hand, foot, and mouth disease (HFMD), which sometimes leads to severe neurological disease and death in the Asia-Pacific region. In Chinese medicine, HFMD is caused mainly by an accumulation of damp-heat and toxicity in the body. No effective drugs are currently available for the treatment and prevention of EV71 infection. This review summarizes the potential Chinese herbal extracts and isolated compounds with antiviral activity against EV71 and their clinical applications, especially those categorized as heat-clearing and detoxifying.
肠道病毒71型（EV71）是手足口病（HFMD）的病原体之一，在亚太地区，手足口病有时会导致严重的神经疾病甚至死亡。在中医中，手足口病主要是由体内湿热和毒素积聚引起的。目前尚无有效的药物可用于治疗和预防EV71感染。本综述总结了具有抗EV71病毒活性的潜在中草药提取物和分离化合物及其临床应用，特别是那些归类为清热排毒的药物。
