Xing Yingshou, Qin Yi, Jing Wei, Zhang Yunxiang, Wang Yanran, Guo Daqing, Xia Yang, Yao Dezhong
Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China ; The School of Electronic Information Engineering, Yangtze Normal University, Chongqing, Fuling, 408100 People's Republic of China.
Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China.
Cogn Neurodyn. 2016 Feb;10(1):23-30. doi: 10.1007/s11571-015-9361-1. Epub 2015 Nov 4.
Patients with temporal lobe epilepsy (TLE) often display cognitive deficits. However, current epilepsy therapeutic interventions mainly aim at how to reduce the frequency and degree of epileptic seizures. Recovery of cognitive impairment is not attended enough, resulting in the lack of effective approaches in this respect. In the pilocarpine-induced temporal lobe epilepsy rat model, memory impairment has been classically reported. Here we evaluated spatial cognition changes at different epileptogenesis stages in rats of this model and explored the effects of long-term Mozart music exposure on the recovery of cognitive ability. Our results showed that pilocarpine rats suffered persisting cognitive impairment during epileptogenesis. Interestingly, we found that Mozart music exposure can significantly enhance cognitive ability in epileptic rats, and music intervention may be more effective for improving cognitive function during the early stages after Status epilepticus. These findings strongly suggest that Mozart music may help to promote the recovery of cognitive damage due to seizure activities, which provides a novel intervention strategy to diminish cognitive deficits in TLE patients.
颞叶癫痫（TLE）患者常表现出认知缺陷。然而，目前的癫痫治疗干预主要旨在如何降低癫痫发作的频率和程度。对认知障碍恢复的关注不足，导致在这方面缺乏有效的方法。在毛果芸香碱诱导的颞叶癫痫大鼠模型中，经典报道存在记忆障碍。在此，我们评估了该模型大鼠在不同癫痫发生阶段的空间认知变化，并探讨了长期暴露于莫扎特音乐对认知能力恢复的影响。我们的结果表明，毛果芸香碱大鼠在癫痫发生过程中存在持续的认知障碍。有趣的是，我们发现暴露于莫扎特音乐可显著提高癫痫大鼠的认知能力，并且音乐干预在癫痫持续状态后的早期阶段可能对改善认知功能更有效。这些发现强烈表明，莫扎特音乐可能有助于促进因癫痫发作活动导致的认知损伤的恢复，这为减少TLE患者的认知缺陷提供了一种新的干预策略。
