Chen Ye, Kong Deyang, Cai Gengyuan, Jiang Zhiguo, Jiao Yiren, Shi Yuzhen, Li Huaqin, Wang Chong
National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, China.
Department of Nephrology, 1st Affiliated Hospital of Harbin Medical University, Harbin, China.
Microb Pathog. 2016 Apr;93:152-7. doi: 10.1016/j.micpath.2016.01.023. Epub 2016 Feb 2.
Reovirus not only causes considerable economic loss in the swine industry of the United States and other countries, but also threatens the public health due to its zoonotic potential. According to previous reports, LiCl has antiviral activity against a number of viruses. The inhibitory effects of LiCl on reovirus life cycle in Vero cells were evaluated. The unpaired t-test and one-way ANOVA were used to analyze the differences between experimental groups. We first found that LiCl treatment significantly inhibited reovirus replication in a dose-dependent manner. Furthermore, we found that this antiviral activity of LiCl targets the early stage of viral replication. LiCl could be a potential drug against reovirus infection.
呼肠孤病毒不仅在美国和其他国家的养猪业中造成了相当大的经济损失，而且由于其人畜共患病潜力，还威胁着公众健康。根据先前的报道，氯化锂对多种病毒具有抗病毒活性。评估了氯化锂对Vero细胞中呼肠孤病毒生命周期的抑制作用。采用非配对t检验和单因素方差分析来分析实验组之间的差异。我们首先发现，氯化锂处理以剂量依赖的方式显著抑制呼肠孤病毒复制。此外，我们发现氯化锂的这种抗病毒活性作用于病毒复制的早期阶段。氯化锂可能是一种抗呼肠孤病毒感染的潜在药物。
