Shen Li, Li Ling-yu, Zhang Xiao-jun, Li Ming, Song Yong-chun
Yao Xue Xue Bao. 2015 Oct;50(10):1305-8.
Three compounds were isolated from solid culture of endophyte Myrothecium roridum IFB-E091 in Artemisia annua. Their structures were determined as (S)-(-)-N-[2-(3-hydroxy-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-acetamide (1), N-(4-hydroxyphenethyl)acetamide (2) and asperfumoid (3), in which compound 1 was a new indole derivative. In cytotoxicity assay, the compound 1 had no obvious inhibition activity in human hepatoma cell line SMMC-7721 and human cervical carcinoma cell line HeLa.
从黄花蒿内生真菌毒色曲霉IFB-E091的固体培养物中分离出三种化合物。它们的结构被确定为(S)-(-)-N-[2-(3-羟基-2-氧代-2,3-二氢-1H-吲哚-3-基)乙基]乙酰胺(1)、N-(4-羟基苯乙基)乙酰胺(2)和asperfumoid(3)，其中化合物1是一种新的吲哚衍生物。在细胞毒性试验中，化合物1对人肝癌细胞系SMMC-7721和人宫颈癌细胞系HeLa没有明显的抑制活性。
