Cornish Toby C, Hruban Ralph H
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, The Johns Hopkins Hospital, Weinberg Building, Room 2242, 401 North Broadway, Baltimore, MD 21231, USA.
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, The Johns Hopkins Hospital, Weinberg Building, Room 2242, 401 North Broadway, Baltimore, MD 21231, USA.
Surg Pathol Clin. 2011 Jun;4(2):523-35. doi: 10.1016/j.path.2011.03.005. Epub 2011 May 30.
Pancreatic intraepithelial neoplasias (PanINs) are microscopic lesions of the pancreas. Traditionally viewed as a benign metaplasia of small ducts, evidence suggests that PanINs are neoplastic and that some PanINs progress to invasive ductal adenocarcinoma. The primary diagnostic challenge is distinguishing PanINs from other lesions, including invasive ductal adenocarcinoma, intraductal papillary mucinous neoplasm, and cancerization of benign ducts. PanINs are the most common of the pancreatic cancer precursor lesions, yet they remain poorly understood and are so small that they are almost clinically undetectable. Further study is required to define the role of PanINs in the carcinogenesis and early detection of pancreatic cancer.
胰腺上皮内瘤变（PanINs）是胰腺的微观病变。传统上被视为小导管的良性化生，但有证据表明PanINs是肿瘤性的，并且一些PanINs会进展为浸润性导管腺癌。主要的诊断挑战是将PanINs与其他病变区分开来，包括浸润性导管腺癌、导管内乳头状黏液性肿瘤以及良性导管的癌变。PanINs是最常见的胰腺癌前体病变，但人们对它们仍知之甚少，而且它们非常小，临床上几乎无法检测到。需要进一步研究来确定PanINs在胰腺癌发生和早期检测中的作用。
