Adeoti M L, Oguntola A S, Akanni E O, Agodirin O S, Oyeyemi G M
Department of Surgery, LAUTECH College of Health Sciences, PMB 4400, Osogbo, Osun State, Nigeria.
Indian J Cancer. 2015 Jan-Mar;52(1):106-9. doi: 10.4103/0019-509X.175573.
There is an indication of the possibility of the direct or indirect influence of trace element in the development and prevention of malignant diseases, the contribution of the trace elements in the etiology of breast cancer has been under scrutiny.
The aim of this study was to determine the serum concentration of trace element in serum of female patients with breast cancer in comparison with healthy controls.
Breast Clinic of the Department of Surgery LAUTECH University teaching hospital Osogbo, in south-western Nigeria.
A cross-sectional age matched controlled prospective study wherein the venous blood sample of 30 patients with breast cancer and 30 healthy volunteers as controls were analyzed using atomic absorption spectrophotometry. The collected data were analyzed using statistical package for the social sciences (SPSS Inc) 16.
The mean serum concentration of the copper, zinc and selenium were 95.3 ± 4.9 ug/dl and 65.2 ± 15 ug/dl, 62.7 ± 15.7 ug/dl and 93.5 ± 7.2 ug/dl, 45.0 ± 4.6 ug/l and 76.4 ± 8.9 ug/l in the two groups respectively. The concentrations of copper and copper-zinc ratio (C/Z) were significantly higher in the cancer bearing group compared to the controls (C/Z 1.6 ± 0.5 against 0.70 ± 0.14 the P < 0.01). The concentration of zinc and selenium in the venous blood of the breast cancer patients showed inverse relationship while that of the control showed a direct relationship (-0.03 against 0.09). In the breast cancer patients the correlation of copper and zinc, copper and selenium and zinc and selenium showed inverse relationships, none of the relationships was statistically significant.
We found a significant association between the serum concentration of trace elements and breast cancer.
有迹象表明微量元素在恶性疾病的发生和预防中可能存在直接或间接影响，微量元素在乳腺癌病因学中的作用一直受到关注。
本研究的目的是测定乳腺癌女性患者血清中微量元素的浓度，并与健康对照进行比较。
尼日利亚西南部奥索博LAUTECH大学教学医院外科乳腺诊所。
一项横断面年龄匹配的对照前瞻性研究，其中使用原子吸收分光光度法分析了30例乳腺癌患者和30名健康志愿者作为对照的静脉血样本。使用社会科学统计软件包（SPSS Inc）16对收集的数据进行分析。
两组中铜、锌和硒的平均血清浓度分别为95.3±4.9μg/dl和65.2±15μg/dl、62.7±15.7μg/dl和93.5±7.2μg/dl、45.0±4.6μg/l和76.4±8.9μg/l。与对照组相比，癌症患者组中铜的浓度和铜锌比（C/Z）显著更高（C/Z为1.6±0.5，而对照组为0.70±0.14，P<0.01）。乳腺癌患者静脉血中锌和硒的浓度呈负相关，而对照组呈正相关（-0.03对0.09）。在乳腺癌患者中，铜与锌、铜与硒以及锌与硒之间的相关性呈负相关，这些关系均无统计学意义。
我们发现微量元素血清浓度与乳腺癌之间存在显著关联。
