Bombonati Alessandro, Lerwill Melinda F
Department of Pathology, Thomas Jefferson University Hospitals, Methodist Division, 2301 South Broad Street, Philadelphia, PA 19148, USA.
James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA; Department of Pathology, Harvard Medical School, 25 Shattuck street, Boston, MA 02115, USA.
Surg Pathol Clin. 2012 Sep;5(3):719-47. doi: 10.1016/j.path.2012.06.004. Epub 2012 Jul 26.
Breast cancer is a common source of systemic metastatic disease. Distinguishing metastatic breast cancer from other types of malignancies can be diagnostically challenging but is important for correct treatment and prognosis. Nonmammary tumors can also metastasize to the breast, although this is a rare phenomenon. Differentiating a metastasis to the breast from a primary breast cancer can likewise be difficult. Knowledge of the clinical history and careful morphologic evaluation are the cornerstones of diagnosis. A panel of immunohistochemical stains tailored to the differential diagnosis at hand can provide helpful information in ambiguous cases.
乳腺癌是系统性转移性疾病的常见来源。将转移性乳腺癌与其他类型的恶性肿瘤区分开来在诊断上具有挑战性，但对于正确的治疗和预后很重要。非乳腺肿瘤也可转移至乳腺，尽管这是一种罕见现象。同样，鉴别乳腺转移瘤与原发性乳腺癌也可能很困难。了解临床病史和仔细的形态学评估是诊断的基石。一组针对手头鉴别诊断的免疫组织化学染色可为疑难病例提供有用信息。
