Lima Valerie, Martinez-Lapus Felycette Gay, Demegillo Kenny Jun
Department of Internal Medicine, Davao Doctors Hospital, Davao City, Philippines.
World J Oncol. 2020 Feb;11(1):37-40. doi: 10.14740/wjon1258. Epub 2020 Feb 2.
The occurrence of breast metastasis from prostate carcinoma and primary breast carcinoma in men may cause a diagnostic dilemma. This report aims to present a patient diagnosed with metastatic castrate-resistant prostatic adenocarcinoma who developed breast metastasis mimicking as a second primary. A 57-year-old male patient presented with a breast mass while undergoing hormonal therapy for prostatic adenocarcinoma. The initial histopathologic diagnosis of the breast specimen was an infiltrating ductal breast carcinoma. The breast mass enlarged after four cycles of docetaxel. Immunostaining with prostate-specific antigen (PSA) and prostate-specific acid phosphatase (PSAP) was done on the breast specimen revealing a negative PSA and a moderately staining PSAP. These stains confirmed the diagnosis of a breast metastasis from prostatic adenocarcinoma. The differentiation between primary breast carcinoma and breast metastasis from prostate carcinoma is crucial. Hence, immunohistochemistry staining should be utilized for diagnosis and appropriate management.
前列腺癌发生男性乳腺转移以及男性原发性乳腺癌可能会导致诊断困境。本报告旨在介绍一名被诊断为转移性去势抵抗性前列腺腺癌的患者，其出现了类似第二原发性肿瘤的乳腺转移。一名57岁男性患者在接受前列腺腺癌激素治疗时出现乳腺肿块。乳腺标本的初始组织病理学诊断为浸润性导管乳腺癌。多西他赛四个周期治疗后乳腺肿块增大。对乳腺标本进行前列腺特异性抗原（PSA）和前列腺特异性酸性磷酸酶（PSAP）免疫染色，结果显示PSA阴性，PSAP呈中度染色。这些染色结果证实了前列腺腺癌乳腺转移的诊断。原发性乳腺癌与前列腺癌乳腺转移的鉴别至关重要。因此，免疫组化染色应用于诊断和适当的治疗管理。
