Matsuyama Satoko, Nohara Takahiro, Kawaguchi Shohei, Seto Chikashi, Nakanishi Yuko, Uchiyama Akio, Ishizawa Shin
Department of Urology, Toyama Prefectural Central Hospital, 2-2-78 Nishinagae, Toyama, Toyama 930-8550, Japan.
Department of Pathology, Toyama Prefectural Central Hospital, 2-2-78 Nishinagae, Toyama, Toyama 930-8550, Japan.
Case Rep Urol. 2015;2015:879584. doi: 10.1155/2015/879584. Epub 2015 Dec 29.
Here, we report a case of stromal tumor of uncertain malignant potential (STUMP) that was difficult to diagnose. A 53-year-old male was found to have a hard nodule on digital rectal examination; magnetic resonance imaging revealed a large nodule on the left side of the prostate, indicating prostate cancer. However, pathological diagnosis of the biopsy specimen was benign prostatic hyperplasia. Although a papillary tumor in the prostatic urethra was also seen on urethrocystoscopy, the tumor specimen obtained from transurethral resection was not malignant. The tumor in the prostatic urethra recurred only 3 months after transurethral resection, and pathological findings revealed benign hyperplasia not only in the stromal tissue but also in the epithelium; therefore, the prostate tumor was suspected to be STUMP. It took many prostate pathologists a long time to reach the final diagnosis of STUMP. STUMP is a rare benign tumor, difficult to diagnose, and sometimes transforms into stromal sarcoma. Thus, we should consider radical resection in such cases.
在此，我们报告一例诊断困难的具有不确定恶性潜能的间质瘤（STUMP）病例。一名53岁男性在直肠指检时发现一个硬结节；磁共振成像显示前列腺左侧有一个大结节，提示前列腺癌。然而，活检标本的病理诊断为良性前列腺增生。尽管在尿道膀胱镜检查中也发现前列腺尿道有乳头状肿瘤，但经尿道切除获得的肿瘤标本并非恶性。前列腺尿道的肿瘤在经尿道切除后仅3个月就复发了，病理结果显示不仅间质组织而且上皮均为良性增生；因此，怀疑前列腺肿瘤为STUMP。众多前列腺病理学家花费了很长时间才最终诊断为STUMP。STUMP是一种罕见的良性肿瘤，难以诊断，有时会转变为间质肉瘤。因此，对于此类病例我们应考虑根治性切除。
