Watanabe Masatoshi, Yamada Yasushi, Kato Hiroya, Imai Hiroshi, Nakano Hiroshi, Araki Tomio, Shiraishi Taizo
Second Department of Pathology, Mie University School of Medicine, Tsu, Japan.
Pathol Int. 2002 Dec;52(12):777-83. doi: 10.1046/j.1440-1827.2002.01417.x.
A case of malignant phyllodes tumor of the prostate in a 67-year-old man is reported. The patient was referred to a hospital for urinary retention. From material taken at three transurethral resections of the prostate (TURP), a histological diagnosis of benign prostatic hyperplasia was made. However, at the fourth TURP, phyllodes tumor was diagnosed due to the presence of elongated epithelial ducts and proliferating cellular stroma with mitosis and nuclear atypia. Two months later, total cystoprostatectomy was performed. Histologically, the tumor was composed of dysplastic stromal cells and irregularly elongated epithelial ducts. Five months later the patient developed multiple lung and pelvic lymph node metastases and died. This report documents progression to a higher histological grade of prostatic phyllodes tumor documented with sequential pathological findings obtained from four TURP and surgical specimens over about 3 years.
报告了一例67岁男性前列腺恶性叶状肿瘤的病例。该患者因尿潴留被转诊至医院。根据三次经尿道前列腺切除术（TURP）获取的材料，做出了良性前列腺增生的组织学诊断。然而，在第四次TURP时，由于存在细长的上皮导管以及伴有有丝分裂和核异型性的增殖性细胞间质，诊断为叶状肿瘤。两个月后，进行了全膀胱前列腺切除术。组织学上，肿瘤由发育异常的间质细胞和不规则细长的上皮导管组成。五个月后，患者出现多处肺和盆腔淋巴结转移并死亡。本报告记录了在约3年时间里通过四次TURP和手术标本获得的连续病理结果所证实的前列腺叶状肿瘤向更高组织学分级的进展情况。
