Machado Michel M, de Oliveira Luis F S, Zuravski Luisa, de Souza Raul O, Fischer Paula, Duarte Jonathaline A, Rocha Manoelly O, Güez Camila M, Boligon Aline A, Athayde Margareth L
Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pampa, Uruguaiana, RS, Brazil.
Programa de Pós-Graduação em Ciências Farmacêuticas, Departamento de Farmácia Industrial, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
An Acad Bras Cienc. 2016 Mar;88(1):17-28. doi: 10.1590/0001-3765201520140076. Epub 2016 Feb 2.
Euphorbia tirucalli (L.), commonly known as aveloz, has been indiscriminately used in popular medicine to treat various illnesses. However, some components can have devastating consequences. Injury to a cell's genetic material can cause mutations, cancer, and cell death. Our main goal in this work was to evaluate the genotoxic and cytotoxic effects of E. tirucalli extract on human leukocytes. For this purpose, we performed a phytochemical analysis to evaluate the plant's components. In the second step, we treated cultured human leukocytes with different concentrations of the dry extract of the plant and then evaluated the oxidative and genotoxic profiles of these leukocytes. We found that at 1% and 10% concentrations, the aveloz extract acted as a genotoxic agent that could damage DNA and increase oxidative damage. We conclude that despite its popular use, aveloz can act as a genotoxic agent, especially when it contains phorbol ester. Aveloz's indiscriminate use might actually promote tumors and therefore carry a considerable genetic risk for its users.
绿玉树（Euphorbia tirucalli (L.)），俗称麻风树，在民间医学中被不加区分地用于治疗各种疾病。然而，其某些成分可能会产生毁灭性后果。对细胞遗传物质的损伤会导致突变、癌症和细胞死亡。我们这项工作的主要目标是评估绿玉树提取物对人类白细胞的遗传毒性和细胞毒性作用。为此，我们进行了植物化学分析以评估该植物的成分。第二步，我们用不同浓度的该植物干燥提取物处理培养的人类白细胞，然后评估这些白细胞的氧化和遗传毒性特征。我们发现，在1%和10%的浓度下，麻风树提取物作为一种遗传毒性剂，会损害DNA并增加氧化损伤。我们得出结论，尽管麻风树被广泛使用，但它可能会作为一种遗传毒性剂起作用，尤其是当它含有佛波酯时。麻风树的不加区分使用实际上可能会促进肿瘤发生，因此对使用者带来相当大的遗传风险。
