基于亚胺交联反应的组织整合性和生物相容性光凝胶化。
Tissue-Integratable and Biocompatible Photogelation by the Imine Crosslinking Reaction.
机构信息
Key Laboratory for Advanced Materials, Institute of Fine Chemicals, East China University of Science and Technology, 130# Meilong Road, Shanghai, 200237, China.
Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiaotong University School of Medicine, 600# Yishan Road, Shanghai, 200233, China.
出版信息
Adv Mater. 2016 Apr 13;28(14):2724-30. doi: 10.1002/adma.201505336. Epub 2016 Feb 3.
A novel photogelling mechanism by the phototriggered-imine-crosslinking (PIC) reaction is demonstrated. Hyaluronic acid grafted with o-nitrobenzene, a photogenerated aldehyde group, can quickly photo-crosslink with amino-bearing polymers or proteins. Once the in situ photogelling on a wound occurs, the PIC gelling process can well integrate a hydrogel with surrounding tissue by covalent bonding, thus making it a powerful tool for tissue engineering and regenerative medicine.
本文展示了一种新颖的光引发肟交联（PIC）反应的光致凝胶机制。具有邻硝基苯甲醛光生醛基的透明质酸可以快速与含氨基的聚合物或蛋白质进行光交联。一旦在伤口上发生原位光致凝胶化，PIC 凝胶化过程可以通过共价键将水凝胶与周围组织很好地整合在一起，因此成为组织工程和再生医学的有力工具。
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