Kaslow J E, Rucker L, Onishi R
Division of Basic and Clinical Immunology, University of California Irvine Medical Center, Orange 92668.
Arch Intern Med. 1989 Nov;149(11):2501-3.
Chronic fatigue syndrome is a recently defined entity for which clinical criteria were proposed by the Centers for Disease Control, Atlanta, Ga. A frequently advocated treatment in Southern California is an injectable solution of bovine liver extract containing folic acid and cyanocobalamin (LEFAC). We conducted a double-blind, placebo-controlled, crossover trial of intramuscular LEFAC in 15 patients who met the Centers for Disease Control criteria for chronic fatigue syndrome. Although patients responded to placebo and LEFAC by several criteria of functional status, no significant difference was apparent between response to placebo and that to LEFAC. The placebo response appeared to be strong.
慢性疲劳综合征是一种最近定义的病症，佐治亚州亚特兰大疾病控制中心为此提出了临床标准。在南加利福尼亚，一种经常被提倡的治疗方法是注射含有叶酸和氰钴胺的牛肝提取物溶液（LEFAC）。我们对15名符合疾病控制中心慢性疲劳综合征标准的患者进行了一项关于肌肉注射LEFAC的双盲、安慰剂对照交叉试验。尽管根据功能状态的几个标准，患者对安慰剂和LEFAC都有反应，但对安慰剂和LEFAC的反应之间没有明显差异。安慰剂反应似乎很强。
