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Mental deterioration in old age: results of two multicenter, clinical trials with nimodipine. The Nimodipine Study Group.老年期精神衰退：两项使用尼莫地平的多中心临床试验结果。尼莫地平研究组
Clin Ther. 1993 Mar-Apr;15(2):394-406.
2
Prevalence of fatigue and chronic fatigue syndrome in a primary care practice.基层医疗实践中疲劳及慢性疲劳综合征的患病率
Arch Intern Med. 1993 Dec 27;153(24):2759-65.
3
n of 1 trials comparing a non-steroidal anti-inflammatory drug with paracetamol in osteoarthritis.在骨关节炎中比较非甾体抗炎药与对乙酰氨基酚的单病例试验。
BMJ. 1994 Oct 22;309(6961):1041-5; discussion 1045-6. doi: 10.1136/bmj.309.6961.1041.
4
General practitioners' attitudes to patients with a self diagnosis of myalgic encephalomyelitis.全科医生对自我诊断为肌痛性脑脊髓炎患者的态度。
BMJ. 1995 Feb 25;310(6978):508. doi: 10.1136/bmj.310.6978.508.
5
Chronic fatigue syndrome: a working case definition.慢性疲劳综合征：实用病例定义
Ann Intern Med. 1988 Mar;108(3):387-9. doi: 10.7326/0003-4819-108-3-387.
6
Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome.肝提取物-叶酸-氰钴胺素与安慰剂治疗慢性疲劳综合征的比较
Arch Intern Med. 1989 Nov;149(11):2501-3.
7
"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician.“简易精神状态检查”。一种供临床医生对患者认知状态进行分级的实用方法。
J Psychiatr Res. 1975 Nov;12(3):189-98. doi: 10.1016/0022-3956(75)90026-6.

单病例试验。慢性疲劳综合征患者的管理：两例病例报告。

N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports.

作者信息

Wiebe E

机构信息

Department of Family Practice, University of British Columbia, Vancouver.

出版信息

Can Fam Physician. 1996 Nov;42:2214-7.

PMID:8939323
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2146911/
Abstract

Chronic fatigue syndrome is a heterogeneous condition with as proves effective treatment. I present two case reports in which N of 1 trials helped me make management decisions. High-dose vitamin B12 injections were ineffective in one case; nimodipine was very effective in the other case.

摘要

慢性疲劳综合征是一种异质性疾病，目前尚无经证实有效的治疗方法。我介绍两例病例报告，其中单病例试验帮助我做出了管理决策。高剂量维生素B12注射在一例中无效；尼莫地平在另一例中非常有效。