Pedal I, Reichert W, Oliveira Corvelo T C
Beitr Gerichtl Med. 1989;47:153-8.
The epithelium of the vesicular glands is immunohistochemically Leb positive in Lewis positive secretors; unexpectedly there is no Lea positivity in Lewis positive Nonsecretors. These findings are confirmed by serological analysis of the vesicular gland secretions. After neuraminidase pretreatment of the tissue sections immunohistochemistry reveals a weak Lea positivity in Lewis positive secretors and a more or less strong Lea positivity in Lewis positive nonsecretors. This observation argues for a close connection between the Lewis system fucosyl transferase and a very effective sialyl transferase in the vesicular gland epithelia; Lea is therefore predominantly secreted in a sialylated form. The vesicular glands seem to be the main source of the antigen CA 19-9 = sialyl-Lea of the seminal plasma.
在Lewis阳性分泌者中，泡状腺上皮免疫组化显示Leb阳性；出乎意料的是，Lewis阳性非分泌者中没有Lea阳性。泡状腺分泌物的血清学分析证实了这些发现。对组织切片进行神经氨酸酶预处理后，免疫组化显示Lewis阳性分泌者中有微弱的Lea阳性，Lewis阳性非分泌者中有或多或少较强的Lea阳性。这一观察结果表明泡状腺上皮中Lewis系统岩藻糖基转移酶与一种非常有效的唾液酸基转移酶之间存在密切联系；因此，Lea主要以唾液酸化形式分泌。泡状腺似乎是精浆中抗原CA 19-9 = 唾液酸化-Lea的主要来源。
