Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology , Number 11 Zhongguancun Beiyitiao, Beijing 100190, China.
State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention , Beijing 100190, China.
ACS Nano. 2016 Mar 22;10(3):3589-96. doi: 10.1021/acsnano.5b08025. Epub 2016 Feb 26.
One of the biggest obstacles for the development of HIV vaccines is how to sufficiently trigger crucial anti-HIV immunities via a safe manner. We herein integrated surface modification-dependent immunostimulation against HIV vaccine and shape-dependent biosafety and designed a safe noncarrier adjuvant based on silver nanorods coated by both polyvinylpyrrolidone (PVP) and polyethylene glycol (PEG). Such silver nanorods can significantly elevate crucial immunities of HIV vaccine and overcome the toxicity, which is a big problem for other existing adjuvants. This study thus provided a principle for designing a safe and high-efficacy material for an adjuvant and allow researchers to really have a safe and effective prophylaxis against HIV. We expect this material approach to be applicable to other types of vaccines, whether they are preventative or therapeutic.
HIV 疫苗发展的最大障碍之一是如何通过安全的方式充分激发关键的抗 HIV 免疫。我们通过将针对 HIV 疫苗的表面修饰依赖型免疫刺激和形状依赖型生物安全性相结合，设计了一种基于银纳米棒的安全无载体佐剂，该银纳米棒同时包覆了聚乙烯吡咯烷酮（PVP）和聚乙二醇（PEG）。这种银纳米棒可以显著提高 HIV 疫苗的关键免疫原性，同时克服其他现有佐剂存在的毒性问题。本研究为设计安全高效的佐剂材料提供了一个原则，使研究人员真正能够安全有效地预防 HIV。我们期望这种材料方法适用于其他类型的疫苗，无论是预防性疫苗还是治疗性疫苗。
