Ninan Neethu, Goswami Nirmal, Vasilev Krasimir
Unit of Science, Technology, Engineering and Mathematics (STEM), The University of South Australia, Mawson Lakes, SA 5095, Australia.
Future Industries Institute, University of South Australia, Mawson Lakes, SA 5095, Australia.
Nanomaterials (Basel). 2020 May 18;10(5):967. doi: 10.3390/nano10050967.
Over the last decades there has been a tremendous volume of research efforts focused on engineering silver-based (nano)materials. The interest in silver has been mostly driven by the element capacity to kill pathogenic bacteria. In this context, the main area of application has been medical devices that are at significant risk of becoming colonized by bacteria and subsequently infected. However, silver nanomaterials have been incorporated in a number of other commercial products which may or may not benefit from antibacterial protection. The rapid expansion of such products raises important questions about a possible adverse influence on human health. This review focuses on examining currently available literature and summarizing the current state of knowledge of the impact of silver (nano)materials on the immune system. The review also looks at various surface modification strategies used to generate silver-based nanomaterials and the immunomodulatory potential of these materials. It also highlights the immune response triggered by various silver-coated implantable devices and provides guidance and perspective towards engineering silver nanomaterials for modulating immunological consequences.
在过去几十年里，大量的研究工作都集中在设计银基（纳米）材料上。对银的兴趣主要源于其杀灭致病细菌的能力。在这种背景下，主要的应用领域是那些有被细菌定植并随后感染的重大风险的医疗设备。然而，银纳米材料已被纳入许多其他商业产品中，这些产品可能受益于抗菌保护，也可能没有受益。此类产品的迅速扩张引发了关于其对人类健康可能产生的不利影响的重要问题。本综述着重于审视现有文献，并总结银（纳米）材料对免疫系统影响的当前知识状态。该综述还探讨了用于制备银基纳米材料的各种表面改性策略以及这些材料的免疫调节潜力。它还强调了各种涂银可植入设备引发的免疫反应，并为设计用于调节免疫后果的银纳米材料提供指导和观点。
