Andrews Jonathan P, Marttala Jaana, Macarak Edward, Rosenbloom Joel, Uitto Jouni
Department of Dermatology and Cutaneous Biology, The Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Department of Dermatology and Cutaneous Biology, The Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA; The Joan and Joel Rosenbloom Research Center for Fibrotic Diseases, Thomas Jefferson University, Philadelphia, PA, USA.
Matrix Biol. 2016 Apr;51:37-46. doi: 10.1016/j.matbio.2016.01.013. Epub 2016 Feb 2.
Keloids, fibroproliferative dermal tumors with effusive accumulation of extracellular matrix (ECM) components, particularly collagen, result from excessive expression of growth factors and cytokines. The etiology of keloids is unknown but they occur after dermal injury in genetically susceptible individuals, and they cause both physical and psychological distress for the affected individuals. Several treatment methods for keloids exist, including the combination therapy of surgical excision followed by intralesional steroid therapy, however, they have high recurrence rate regardless of the current treatment method. Improved understanding of the pathomechanisms leading to keloid formation will hopefully identify pathways that serve as specific targets to improve therapy for this devastating, currently intractable, disorder.
瘢痕疙瘩是一种纤维增生性皮肤肿瘤，伴有细胞外基质（ECM）成分，特别是胶原蛋白的大量积聚，由生长因子和细胞因子的过度表达引起。瘢痕疙瘩的病因尚不清楚，但在遗传易感个体的皮肤损伤后会出现，给受影响的个体带来身体和心理上的痛苦。目前有几种治疗瘢痕疙瘩的方法，包括手术切除后病灶内注射类固醇的联合治疗，然而，无论采用何种治疗方法，其复发率都很高。更好地理解导致瘢痕疙瘩形成的发病机制有望找到可作为特定靶点的途径，以改善对这种破坏性的、目前难以治疗的疾病的治疗。
