Giménez-Arnau Ana
Department of Dermatology, Hospital del Mar, Institut Hospital del Mar d'Investigacions Mediques (IMIM), Universitat Autònoma de Barcelona, Barcelona, Spain.
Curr Probl Dermatol. 2016;49:123-34. doi: 10.1159/000441588. Epub 2016 Feb 4.
The skin is a vital organ, and through our skin we are in close contact with the entire environment. If we lose our skin we lose our life. The barrier function of the skin is mainly driven by the sophisticated epidermis in close relationship with the dermis. The epidermal epithelium is a mechanically, chemically, biologically and immunologically active barrier submitted to continuous turnover. The barrier function of the skin needs to be protected and restored. Its own physiology allows its recovery, but many times this is not sufficient. This chapter is focused on the standards to restore, treat and prevent barrier function disruption. These standards were developed from a scientific, academic and clinical point of view. There is a lack of standardized administrative recommendations. Still, there is a walk to do that will help to reduce the social and economic burden of diseases characterized by an abnormal skin barrier function.
皮肤是一个重要器官,通过皮肤我们与整个环境密切接触。如果失去皮肤,我们就会失去生命。皮肤的屏障功能主要由与真皮密切相关的复杂表皮驱动。表皮上皮是一个机械、化学、生物和免疫活性的屏障,处于持续更新状态。皮肤的屏障功能需要得到保护和恢复。其自身的生理机能使其能够恢复,但很多时候这并不足够。本章重点关注恢复、治疗和预防屏障功能破坏的标准。这些标准是从科学、学术和临床角度制定的。缺乏标准化的管理建议。不过,仍有一段路要走,这将有助于减轻以皮肤屏障功能异常为特征的疾病的社会和经济负担。